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Table 4 Comparison of pharmacokinetic (PK) parameters in male and female subjects after single-dose administration of 2 mg tablets in healthy Chinese volunteers

From: Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population

PK parameter male(n = 5) female(n = 5) all(n = 10)
Mean SD Mean SD Mean SD
Kel(1/h) 0.0855 0.0054 0.0930 0.0150 0.0892 0.0113
t1/2(h) 8.13 0.50 7.59 1.03 7.86 0.82
tmax(h) 2.25 1.09 3.40 0.89 2.83 1.12
Cmax(ng/ml) 11.7236 3.9680 11.2417 3.4355 11.4826 3.5083
AUC0-t(ng·h/ml) 77.63 18.06 99.48 32.40 88.55 27.28
AUC0-∞(ng·h/ml) 78.78 18.38 100.66 32.88 89.72 27.63
Vd(ml) 156,393 42,435 114,794 26,385 135,593 39,880
CL(ml/h) 13,250.6 3023.2 10,611.3 2644.6 11,930.9 3017.5
MRT0-t(h) 9.51 1.07 10.28 1.55 9.90 1.32
MRT0-∞(h) 10.24 1.23 10.84 1.80 10.54 1.48
  1. All values are mean (±SD)
  2. Kel Rate constant for elimination, t 1/2 Apparent plasma terminal elimination half-life, tmax Time to maximum plasma concentration, C max Maximum plasma concentration, AUC 0-t AUC from 0 h to time t, AUC 0-∞ AUC from time 0 extrapolated to infinity, Vd Volume of distribution during terminal elimination phase, CL Apparent clearance, MRT 0-t The average residence time of zero time to t, MRT 0-∞ The average residence time of zero time to infinite time