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Table 5 Comparison of pharmacokinetic (PK) parameters in male and female subjects after multipledose of 0.5 mg metolazone tablets

From: Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population

PK parameter

male(n = 5)

female(n = 5)

all(n = 10)

Mean

SD

Mean

SD

Mean

SD

Kel(1/h)

0.0871

0.0250

0.1042

0.0186

0.0957

0.0227

t1/2(h)

8.41

2.00

6.82

1.19

7.61

1.76

tmax(h)

1.55

0.41

1.70

0.45

1.63

0.41

Cmax(ng/ml)

7.4484

1.5539

8.9449

2.4602

8.1967

2.0941

AUC0-t(ng·h/ml)

50.05

13.97

52.64

17.56

51.35

15.02

AUC0-∞(ng·h/ml)

51.18

14.42

53.33

17.74

52.26

15.28

Cmin(ng/ml)

0.4646

0.2596

0.3278

0.1888

0.3962

0.2258

Cavg(ng/ml)

1.8842

0.4668

2.0349

0.5978

1.9595

0.5118

DF(%)

382.5

80.7

448.7

192.2

415.6

143.3

CL(ml/h)

11,630.9

2958.5

10,903.6

2861.5

11,267.2

2770.6

MRT0-∞(h)

9.59

2.23

8.36

1.62

8.97

1.94

Vd(ml)

140,134

46,822

104,116

19,283

122,125

38,729

AUCss(ng·h/ml)

45.22

11.20

48.84

14.35

47.03

12.28

Accumulation

1.17

0.08

1.10

0.04

1.13

0.07

DF/τ

15.9

3.4

18.7

8.0

17.3

6.0

  1. All values are mean (±SD)
  2. Kel Rate constant for elimination, t 1/2 Apparent plasma terminal elimination half-life, t max Time to maximum plasma concentration, C max Maximum plasma concentration, AUC 0-t AUC from 0 h to time t, AUC 0-∞ AUC from time 0 extrapolated to infinity, C min Minimum observed concentration, C avg Average plasma concentration, DF Fluctuation, CL Apparent clearance, MRT 0-∞ The average residence time of zero time to infinite time, Vd Volume of distribution during terminal elimination phase, AUCss AUC of distribution at steady state, DF/τ Fluctuation