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Table 5 Comparison of pharmacokinetic (PK) parameters in male and female subjects after multipledose of 0.5 mg metolazone tablets

From: Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population

PK parameter male(n = 5) female(n = 5) all(n = 10)
Mean SD Mean SD Mean SD
Kel(1/h) 0.0871 0.0250 0.1042 0.0186 0.0957 0.0227
t1/2(h) 8.41 2.00 6.82 1.19 7.61 1.76
tmax(h) 1.55 0.41 1.70 0.45 1.63 0.41
Cmax(ng/ml) 7.4484 1.5539 8.9449 2.4602 8.1967 2.0941
AUC0-t(ng·h/ml) 50.05 13.97 52.64 17.56 51.35 15.02
AUC0-∞(ng·h/ml) 51.18 14.42 53.33 17.74 52.26 15.28
Cmin(ng/ml) 0.4646 0.2596 0.3278 0.1888 0.3962 0.2258
Cavg(ng/ml) 1.8842 0.4668 2.0349 0.5978 1.9595 0.5118
DF(%) 382.5 80.7 448.7 192.2 415.6 143.3
CL(ml/h) 11,630.9 2958.5 10,903.6 2861.5 11,267.2 2770.6
MRT0-∞(h) 9.59 2.23 8.36 1.62 8.97 1.94
Vd(ml) 140,134 46,822 104,116 19,283 122,125 38,729
AUCss(ng·h/ml) 45.22 11.20 48.84 14.35 47.03 12.28
Accumulation 1.17 0.08 1.10 0.04 1.13 0.07
DF/τ 15.9 3.4 18.7 8.0 17.3 6.0
  1. All values are mean (±SD)
  2. Kel Rate constant for elimination, t 1/2 Apparent plasma terminal elimination half-life, t max Time to maximum plasma concentration, C max Maximum plasma concentration, AUC 0-t AUC from 0 h to time t, AUC 0-∞ AUC from time 0 extrapolated to infinity, C min Minimum observed concentration, C avg Average plasma concentration, DF Fluctuation, CL Apparent clearance, MRT 0-∞ The average residence time of zero time to infinite time, Vd Volume of distribution during terminal elimination phase, AUCss AUC of distribution at steady state, DF/τ Fluctuation