PK parameter | male(n = 5) | female(n = 5) | all(n = 10) | |||
---|---|---|---|---|---|---|
Mean | SD | Mean | SD | Mean | SD | |
Kel(1/h) | 0.0871 | 0.0250 | 0.1042 | 0.0186 | 0.0957 | 0.0227 |
t1/2(h) | 8.41 | 2.00 | 6.82 | 1.19 | 7.61 | 1.76 |
tmax(h) | 1.55 | 0.41 | 1.70 | 0.45 | 1.63 | 0.41 |
Cmax(ng/ml) | 7.4484 | 1.5539 | 8.9449 | 2.4602 | 8.1967 | 2.0941 |
AUC0-t(ng·h/ml) | 50.05 | 13.97 | 52.64 | 17.56 | 51.35 | 15.02 |
AUC0-∞(ng·h/ml) | 51.18 | 14.42 | 53.33 | 17.74 | 52.26 | 15.28 |
Cmin(ng/ml) | 0.4646 | 0.2596 | 0.3278 | 0.1888 | 0.3962 | 0.2258 |
Cavg(ng/ml) | 1.8842 | 0.4668 | 2.0349 | 0.5978 | 1.9595 | 0.5118 |
DF(%) | 382.5 | 80.7 | 448.7 | 192.2 | 415.6 | 143.3 |
CL(ml/h) | 11,630.9 | 2958.5 | 10,903.6 | 2861.5 | 11,267.2 | 2770.6 |
MRT0-∞(h) | 9.59 | 2.23 | 8.36 | 1.62 | 8.97 | 1.94 |
Vd(ml) | 140,134 | 46,822 | 104,116 | 19,283 | 122,125 | 38,729 |
AUCss(ng·h/ml) | 45.22 | 11.20 | 48.84 | 14.35 | 47.03 | 12.28 |
Accumulation | 1.17 | 0.08 | 1.10 | 0.04 | 1.13 | 0.07 |
DF/τ | 15.9 | 3.4 | 18.7 | 8.0 | 17.3 | 6.0 |