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Table 6 Pharmacokinetic parameters of metolazone after a single oral 1 mg dose: effect of food

From: Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population

  Metolazone(1 mg)
Parameter Fasted (n = 10) Fed (n = 10)
Kel (1/h)
tmax (h)
0.0966 ± 0.0123
1.43 ± 0.39
0.0892 ± 0.0113
2.83 ± 1.12
t1/2(h) 7.28 ± 0.93 7.86 ± 0.82
Cmax (ng/mL) 13.8666 ± 4.3227 11.4826 ± 3.5083
AUC0–t (h•ng/mL) 91.31 ± 30.39 88.55 ± 27.28
AUC0–∞ (h•ng/mL) 92.41 ± 31.38 89.72 ± 27.63
Vd(ml) 120,081 ± 23,585 135,593 ± 39,880
CL(ml/h) 11,755.6 ± 3252.2 11,930.9 ± 3017.5
MRT0-t (h) 8.80 ± 1.50 9.90 ± 1.32
MRT0-∞ (h) 9.31 ± 1.77 10.54 ± 1.48
  1. All values are mean (±SD)
  2. Kel Rate constant for elimination, t 1/2 Apparent plasma terminal elimination half-life, t max Time to maximum plasma concentration, C max Maximum plasma concentration, AUC 0-t AUC from 0 h to time t, AUC 0-∞ AUC from time 0 extrapolated to infinity, Vd Volume of distribution during terminal elimination phase, CL Apparent clearance, MRT 0-t The average residence time of zero time to t, MRT 0-∞ The average residence time of zero time to infinite time