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Table 4 Table 3

From: Methylxanthines induce structural and functional alterations of the cardiac system in zebrafish embryos

  Cardiovascular endpoints
Methylxanthine Dose Pericardial edema Decreased blood flow Absent blood flow Thrombosis Hemorrhage
Aminophylline LC 2% 1% 1% 0 0
HC 14% 16% 6% 0 2%
Caffeine LC 0.01% 0.01% 0 0 0
HC 12% 6.5% 9.8% 0 5.4%
Diprophylline LC 0.01% 0.01% 0.01% 0 0
HC 7.8% 4.95% 2.94% 0 0.01%
Doxofylline LC 4% 4% 12% 0 0
HC 13.7% 8.21% 11% 0 0
Etofylline LC 0.8% 3% 2.5% 0 0
HC 10.2% 5.6% 7.8% 0 0
IBMX LC 3.8% 0 0.03% 0 0
HC 18% 12.5% 15.3% 0 0.01%
Pentoxifylline LC 0 0 0 0 0
HC 8.5% 8.5% 5.7% 0 0
Theophylline LC 0.01% 0.01% 0 0 0
HC 17% 9.2% 13.8% 0 7.7%
  1. Affected endpoints of cardiovascular system at 48 hpf. The table illustrate the percentage of embryos with a particular endpoint affected at the lowest and highest tested concentration
  2. LC lowest concentration, HC highest concentration
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