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Table 4 Table 3

From: Methylxanthines induce structural and functional alterations of the cardiac system in zebrafish embryos

 

Cardiovascular endpoints

Methylxanthine

Dose

Pericardial edema

Decreased blood flow

Absent blood flow

Thrombosis

Hemorrhage

Aminophylline

LC

2%

1%

1%

0

0

HC

14%

16%

6%

0

2%

Caffeine

LC

0.01%

0.01%

0

0

0

HC

12%

6.5%

9.8%

0

5.4%

Diprophylline

LC

0.01%

0.01%

0.01%

0

0

HC

7.8%

4.95%

2.94%

0

0.01%

Doxofylline

LC

4%

4%

12%

0

0

HC

13.7%

8.21%

11%

0

0

Etofylline

LC

0.8%

3%

2.5%

0

0

HC

10.2%

5.6%

7.8%

0

0

IBMX

LC

3.8%

0

0.03%

0

0

HC

18%

12.5%

15.3%

0

0.01%

Pentoxifylline

LC

0

0

0

0

0

HC

8.5%

8.5%

5.7%

0

0

Theophylline

LC

0.01%

0.01%

0

0

0

HC

17%

9.2%

13.8%

0

7.7%

  1. Affected endpoints of cardiovascular system at 48 hpf. The table illustrate the percentage of embryos with a particular endpoint affected at the lowest and highest tested concentration
  2. LC lowest concentration, HC highest concentration