| |
Cardiovascular endpoints
|
|---|
|
Methylxanthine
|
Dose
|
Pericardial edema
|
Decreased blood flow
|
Absent blood flow
|
Thrombosis
|
Hemorrhage
|
|---|
|
Aminophylline
|
LC
|
2%
|
1%
|
1%
|
0
|
0
|
|
HC
|
14%
|
16%
|
6%
|
0
|
2%
|
|
Caffeine
|
LC
|
0.01%
|
0.01%
|
0
|
0
|
0
|
|
HC
|
12%
|
6.5%
|
9.8%
|
0
|
5.4%
|
|
Diprophylline
|
LC
|
0.01%
|
0.01%
|
0.01%
|
0
|
0
|
|
HC
|
7.8%
|
4.95%
|
2.94%
|
0
|
0.01%
|
|
Doxofylline
|
LC
|
4%
|
4%
|
12%
|
0
|
0
|
|
HC
|
13.7%
|
8.21%
|
11%
|
0
|
0
|
|
Etofylline
|
LC
|
0.8%
|
3%
|
2.5%
|
0
|
0
|
|
HC
|
10.2%
|
5.6%
|
7.8%
|
0
|
0
|
|
IBMX
|
LC
|
3.8%
|
0
|
0.03%
|
0
|
0
|
|
HC
|
18%
|
12.5%
|
15.3%
|
0
|
0.01%
|
|
Pentoxifylline
|
LC
|
0
|
0
|
0
|
0
|
0
|
|
HC
|
8.5%
|
8.5%
|
5.7%
|
0
|
0
|
|
Theophylline
|
LC
|
0.01%
|
0.01%
|
0
|
0
|
0
|
|
HC
|
17%
|
9.2%
|
13.8%
|
0
|
7.7%
|
- Affected endpoints of cardiovascular system at 48 hpf. The table illustrate the percentage of embryos with a particular endpoint affected at the lowest and highest tested concentration
-
LC lowest concentration, HC highest concentration
