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Fig. 2 | BMC Pharmacology and Toxicology

Fig. 2

From: Generic-reference and generic-generic bioequivalence of forty-two, randomly-selected, on-market generic products of fourteen immediate-release oral drugs

Fig. 2

Average bioequivalence of randomly-selected generic products to the reference product of 14 immediate-release, non-combinational, oral drugs. Each reference product (R) was compared to 3 generic products (Ga, Gb, Gc). Data represent generic/reference geometric mean ratios and unadjusted 90% confidence intervals. The shaded area indicates the area of bioequivalence (80.00%–125.00%). a Evaluation of area-under-the-concentration-time curve to time of maximum concentration of reference product, calculated for each subject (AUCReftmax). b Evaluation of area-under-the-concentration-time curve truncated to 72 h (AUC72). Only 2 drugs (amlodipine and fluconazole) in this study have terminal half-life >72 h

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