Fig. 1

Effects of enoxaparin (ENX) treatment on cardiotoxicity, antioxidant, inflammatory and apoptosis parameters on doxorubicin (DOX)-induced cardiomyopathy in male Wistar albino rats. Graph illustrates changes in (a) serum levels of cardiac troponin I (cTnI), (b) serum levels of brain natriuretic peptide (BNP), (c) cardiac tissue malondialdehyde (MDA), (d) cardiac tissue total antioxidant capacity (TAC), (e) cardiac tissue tumor necrosis factor alpha (TNF-α), (f) cardiac tissue interleukin 1-beta (IL-1β) and (g) cardiac tissue caspase-3 (casp-3) in control (n = 7), DOX (n = 6) and DOX plus ENX (n = 6) experimental groups. All data is presented as mean ± SEM, analyzed by one-way ANOVA followed by Fisher’s least significant difference (LSD) test. ^a P ≤ 0.05 for DOX vs. control; ^b P ≤ 0.05 for ENX plus DOX vs. DOX and ^c P ≤ 0.05 for ENX plus DOX vs. control