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Fig. 2 | BMC Pharmacology and Toxicology

Fig. 2

From: Enoxaparin attenuates doxorubicin induced cardiotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis

Fig. 2

Photomicrographs of myocardium sections taken at 400X magnification (ac) and cardiomyopathy (CMY) severity scores graded from 0 to 4: 0 represents no lesion, 1 represents mild lesion, 2 represents moderate lesion and 3 or more represents severe lesion. a Control group which shows normal architecture of myocardium (score range = 0), (b) Doxorubicin (DOX) group which demonstrates severe lesion with congestion of myocardial vessels, disorganization of myocardial fibers, myocardial fiber swelling (black arrow), myofibrillar loss (black arrowhead) and vacuolization of the cytoplasm (yellow arrow) and perinuclear vacuolization (yellow arrowhead) (score range = 3–4), and (c) Enoxaparin (ENX) plus DOX group which shows mild to moderate lesion that is characterized by disorganization of myocardial fibers and myocardial fiber swelling (black arrow) with less cytoplasm (yellow arrow) and perinuclear vacuolization (yellow arrowhead) and no myofibrillar loss (score range = 1–3), and (D) Overall CMY scores presented as mean ± SEM., analyzed by one-way ANOVA followed by Fisher’s least significant difference (LSD) test. a P ≤ 0.05 for DOX vs. control; b P ≤ 0.05 for ENX plus DOX vs. DOX and c P ≤ 0.05 for ENX plus DOX vs. control

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