TY - JOUR AU - Forkuo, Arnold Donkor AU - Ansah, Charles AU - Pearson, David AU - Gertsch, Werner AU - Cirello, Amanda AU - Amaral, Adam AU - Spear, Jaimie AU - Wright, Colin W. AU - Rynn, Caroline PY - 2017 DA - 2017/12/22 TI - Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats JO - BMC Pharmacology and Toxicology SP - 84 VL - 18 IS - 1 AB - This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites in rat plasma and urine after a single cryptolepine dose, and evaluating the single-dose oral and intravenous pharmacokinetics of cryptolepine in male Sprague Dawley (SD) rats. SN - 2050-6511 UR - https://doi.org/10.1186/s40360-017-0188-8 DO - 10.1186/s40360-017-0188-8 ID - Forkuo2017 ER -