Fig. 2

Proposed metabolite structures and metabolic pathways for cryptolepine determined by LC-MS/MS after incubation with rat and human hepatocytes for up to 24 h and in plasma and urine of SD rats after single dose oral administration of cryptolepine. R: detected after rat hepatocyte incubation; H: detected after human hepatocyte incubation. * Metabolite detected in rat urine; ** metabolite detected in rat urine and plasma