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Table 2 Pharmacokinetic parameters of cryptolepine in rats following intravenous administration at a dose of 1 mg/kg

From: Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats

Animal ID Plasma AUC0–7h (nM.h) CLp (mL/min/kg) Vss (L/Kg) t1/2 (h) MRT (h) Urine Ae0-24h (% dose)
1 106 521 147 3 5 0.22
2 109 402 180 6 7 0.84
  1. AUC0–7h, the area under the concentration-time curve up to the last measurable time point in plasma; CLp, plasma clearance; Vss, steady-state volume of distribution; t1/2, elimination half-life; Tmax; MRT, mean residence time; Ae0-24h, amount excreted within 24 h following administration