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Table 2 Pharmacokinetic parameters of cryptolepine in rats following intravenous administration at a dose of 1 mg/kg

From: Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats

Animal ID

Plasma AUC0–7h (nM.h)

CLp (mL/min/kg)

Vss (L/Kg)

t1/2 (h)

MRT (h)

Urine Ae0-24h (% dose)

1

106

521

147

3

5

0.22

2

109

402

180

6

7

0.84

  1. AUC0–7h, the area under the concentration-time curve up to the last measurable time point in plasma; CLp, plasma clearance; Vss, steady-state volume of distribution; t1/2, elimination half-life; Tmax; MRT, mean residence time; Ae0-24h, amount excreted within 24 h following administration
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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