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Table 3 Pharmacokinetic parameters of cryptolepine in rats following oral administration at a dose of 5 mg/kg

From: Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats

Animal ID

Plasma AUC0–7 (nM.h)

Cmax (nM)

Tmax (h)

F %

Urine Ae0-24h (% dose)

3

83

28

0.3

16

0.15

4

146

104

0.5

28

0.12

  1. AUC0–7h, the area under the concentration-time curve up to the last measurable time point in plasma; Cmax, maximum plasma concentration; Tmax, time to reach Cmax; F, oral bioavailability; Ae0-24h, amount excreted within 24 h following administration
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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