From: Pharmacokinetics comparison of two pegylated interferon alfa formulations in healthy volunteers
Parameters | PEGASYS® | BIP48 | P-Value (ANOVA) | |
---|---|---|---|---|
Tmax (hours) | Mean | 54 | 73 | 0.001 |
SD | 18 | 22 | ||
Cmax (pg/ml) | Mean | 19,960 | 18,630 | 0.3185 |
SD | 7066 | 8641 | ||
Ke (h-1) | Mean | 0.013 | 0.011 | 0.0153 |
SD | 0.007 | 0.013 | ||
T ½ (hours) | Mean | 107.8 | 191.8 | 0.0218 |
SD | 69.3 | 128.7 | ||
AUC(0–336) (pg/h/ml) | Mean | 3,393,567 | 3,585,383 | 0.4649 |
SD | 1,562,761 | 2,197,201 | ||
AUC(0-inf) (pg/h/ml) | Mean | 4,274,458 | 5,874,658 | 0.0053 |
SD | 2,373,083 | 4,066,639 |