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Table 2 Means and standard deviations for pharmacokinetic parameters

From: Pharmacokinetics comparison of two pegylated interferon alfa formulations in healthy volunteers

Parameters

 

PEGASYS®

BIP48

P-Value (ANOVA)

Tmax (hours)

Mean

54

73

0.001

SD

18

22

Cmax (pg/ml)

Mean

19,960

18,630

0.3185

SD

7066

8641

Ke (h-1)

Mean

0.013

0.011

0.0153

SD

0.007

0.013

T ½ (hours)

Mean

107.8

191.8

0.0218

SD

69.3

128.7

AUC(0–336) (pg/h/ml)

Mean

3,393,567

3,585,383

0.4649

SD

1,562,761

2,197,201

AUC(0-inf) (pg/h/ml)

Mean

4,274,458

5,874,658

0.0053

SD

2,373,083

4,066,639