Table 3 Noncompartmental analysis (Statistical Model) of pharmacokinetic measures for formulations A and B
From: Pharmacokinetics comparison of two pegylated interferon alfa formulations in healthy volunteers
Parameters | PEGASYS® | BIP48 | P-Value (ANOVA) | |
|---|---|---|---|---|
MRT(0–336) | Mean | 115 | 133 | 0.0324 |
(hours) CAV(0–336) | SD | 27 | 37 | |
Mean | 0.006 | 0.007 | 0.3843 | |
MRT (0-inf) | SD | 0.002 | 0.004 | |
Mean | 177 | 300 | 0.0003 | |
(hours) | SD | 82 | 172 | |
CAV (0-inf) | Mean | 0.005 | 0.005 | 0.2702 |
SD | 0.002 | 0.004 | ||
MAT | Mean | 28.1 | 30.9 | 0.2992 |
SD | 17 | 13.1 | ||
HVD | Mean | 161 | 216 | 0.3591 |
(hours) | SD | 38 | 101 | |