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Table 3 Estimated parameters from the final MBPK model to evaluate effect of food on fenofibrate absorption and results from bootstrap

From: A mechanism-based pharmacokinetic model of fenofibrate for explaining increased drug absorption after food consumption

Parameters Estimates (% RSE) IIV %CV (% RSE) IOV %CV (% RSE) Bootstrap median ± S.E.
k g (hr−1) 0.0412 (8.5%) 31.7% (22.1%) 0.042 ± 0.0033
k m&a (hr− 1) 0.198 (28.9%) 0.172 ± 0.057
k el (hr− 1) 0.27 (13. 6%) 86.3% (29.2%) 44.9% (43.5%) 0.28 ± 0.048
V c /F (L) 12.9 (27.8%) 93% (28.9%) 50.9% (22.6%) 11.91 ± 2.55
V stomach (L) 0.049a/1a 0.049a/1a
V duodenum (L) 0.045a 0.045a
k g (hr−1) 0.00971 (58.9%) 0.011 ± 0.005
k out (hr−1) 0.00972 (38.3%) 0.011 ± 0.005
E bile 0.0239 (22.2%) 0.027 ± 0.091
MTIME1 (hr) 0a 0a
MTIME2 (hr) 6.94 (12.4%) 6.92 ± 1.11
E food 0.617 (40.4%) 0.64 ± 0.19
E Vc1 −0.394 (40.1%) − 0.38 ± 0.12
E Vc2 −0.461 (37.7%) − 0.43 ± 0.14
Residual variability  
Proportional error (% RSE) 0.608 (6.4%)    0.599 ± 0.038
  1. aFixed parameter