Table 3 Estimated parameters from the final MBPK model to evaluate effect of food on fenofibrate absorption and results from bootstrap

k _g (hr⁻¹)

0.0412 (8.5%)

31.7% (22.1%)

–

0.042 ± 0.0033

k _m&a (hr^− 1)

0.198 (28.9%)

–

–

0.172 ± 0.057

k _el (hr^− 1)

0.27 (13. 6%)

86.3% (29.2%)

44.9% (43.5%)

0.28 ± 0.048

V _c /F (L)

12.9 (27.8%)

93% (28.9%)

50.9% (22.6%)

11.91 ± 2.55

V _stomach (L)

0.049^a/1^a

–

–

0.049^a/1^a

V _duodenum (L)

0.045^a

–

–

0.045^a

k _g ’ (hr⁻¹)

0.00971 (58.9%)

–

–

0.011 ± 0.005

k _out (hr⁻¹)

0.00972 (38.3%)

–

–

0.011 ± 0.005

E _bile

0.0239 (22.2%)

–

–

0.027 ± 0.091

MTIME1 (hr)

0^a

–

–

0^a

MTIME2 (hr)

6.94 (12.4%)

–

–

6.92 ± 1.11

E _food

0.617 (40.4%)

–

–

0.64 ± 0.19

E _Vc1

−0.394 (40.1%)

–

–

− 0.38 ± 0.12

E _Vc2

−0.461 (37.7%)

–

–

− 0.43 ± 0.14

Proportional error (% RSE)

0.608 (6.4%)

0.599 ± 0.038