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Table 4 Cmax and AUC168➔192 of fenofibric acid at steady state from simulated data using final MBPK model and results of ANOVA

From: A mechanism-based pharmacokinetic model of fenofibrate for explaining increased drug absorption after food consumption

Mean ± S.E.

Group 1

Group 2

Group 3

Food type

Fasting condition

Normal meal

High fat meal

Cmax (μ g/mL)

3.17 ± 0.07

4.33 ± 0.10*

4.83 ± 0.11*†

AUC168➔192 (μ g∙hr./mL)

319.14 ± 7.48

432.90 ± 10.33*

483.63 ± 11.55*†

  1. *: p < 0.01 vs the Group 1; : p < 0.01 vs the Group 2