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Table 4 Cmax and AUC168➔192 of fenofibric acid at steady state from simulated data using final MBPK model and results of ANOVA

From: A mechanism-based pharmacokinetic model of fenofibrate for explaining increased drug absorption after food consumption

Mean ± S.E. Group 1 Group 2 Group 3
Food type Fasting condition Normal meal High fat meal
Cmax (μ g/mL) 3.17 ± 0.07 4.33 ± 0.10* 4.83 ± 0.11*†
AUC168➔192 (μ g∙hr./mL) 319.14 ± 7.48 432.90 ± 10.33* 483.63 ± 11.55*†
  1. *: p < 0.01 vs the Group 1; : p < 0.01 vs the Group 2