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Table 5 Increased (or decreased) pharmacokinetic parameters values and percent change of fenofibrate after consumption of food, relative to fasted state

From: A mechanism-based pharmacokinetic model of fenofibrate for explaining increased drug absorption after food consumption

 

Standard meal (686.3 kcal)

High fat meal (908 kcal)

k g

0.067 h− 1 (+ 61.7%)

k m&a

0.23 h− 1 (+ 16.5%)

0.24 h− 1 (+ 21.8%)

Vc/F

7.82 L (− 39.4%)

6.95 L (− 46.1%)

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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