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Table 1 Tabun-inhibited acetylcholinesterase reactivation constants

From: A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase

  HUMAN RAT  
Constants K R
[μM]
k R
[min−1]
k r
[min− 1. M− 1]
k r c
[min− 1. M− 1]
Species
Difference ratio
Oxime
Pralidoxime - a - a - a 10 - b
Obidoxime 1412 0.060 42 6250 149
Asoxime (HI-6) - a - a - a 1111 - b
K203 56 0.120 2142 16,000 7.5
  1. a, bUnable to estimate the appropriate constants due to lack of reactivated AChE by this oxime
  2. cRat brain homogenate results published by Musilek et al. J. Med. Chem. (2007)