BMC Pharmacology and Toxicology

Table 1 Tabun-inhibited acetylcholinesterase reactivation constants

From: A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase

	HUMAN			RAT
Constants	K _R [μM]	k _R [min⁻¹]	k _r [min^− 1. M^− 1]	k _r ^c [min^− 1. M^− 1]	Species Difference ratio
Oxime	K _R [μM]	k _R [min⁻¹]	k _r [min^− 1. M^− 1]	k _r ^c [min^− 1. M^− 1]	Species Difference ratio
Pralidoxime	- ^a	- ^a	- ^a	10	- ^b
Obidoxime	1412	0.060	42	6250	149
Asoxime (HI-6)	- ^a	- ^a	- ^a	1111	- ^b
K203	56	0.120	2142	16,000	7.5

^{a, b}Unable to estimate the appropriate constants due to lack of reactivated AChE by this oxime
^cRat brain homogenate results published by Musilek et al. J. Med. Chem. (2007)

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ISSN: 2050-6511

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