Fig. 1

Western blot showing APD-induced changes in the expression of the HIST1H4B, HSPA8, NCL, NPM1, and VIM proteins in C6 and B35 cells and the rat cortex. Nuclear protein extracts collected from APD-treated C6 cells, B35 cells and rat cortex were compared. a and (b), HIST1H4B; (c) and (d),HSPA8; (e) and (f), NCL; (g) and (h), NPM1; (i) and (j), VIM. Bar charts were constructed from triplicate western blot data obtained from three different batches of APD-treated cells or rat cortices using ANOVA followed by Dunnett’s test (*p-value < 0.05; **p-value < 0.01). Haloperidol (HAL), risperidone (RIS), clozapine (CLO), or PBS (control group, CTRL))