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Table 4 Relative expression of Hist1h4b, Hspa8, Ncl, Npm1, Plec, and Vim genes in C6 and B35 cells after sub-chronic treatment by haloperidol, risperidone, or clozapine

From: Proteomic study revealed antipsychotics-induced nuclear protein regulations in B35 cells are similar to the regulations in C6 cells and rat cortex

  C6 B35
Gene Group Fold Mean ± SD p-valnea MD F df ANOVA-p Fold Mean ± SD p-valne MD F df ANOVA-p
Hist1h4b CTRL 1.00 ± 0.183    8.374 12 0.003 1.00 ± 0.199    22.561 12 0.000
HAL 1.67 ± 0.091 0.764 0.6748 2.23 ± 0.629 0.198 1.2308
RIS 0.90 ± 0.811 0.999 −0.0961 3.03 ± 0.778 0.024 b 2.0262*
CLO 4.56 ± 2.221 0.003b 3.5581* 6.17 ± 1.554 0.000 b 5.1730*
Hspa8 CTRL 1.00 ± 0.063    298.9 12 0.000 1.00 ± 0.196    0.690 12 0.575
HAL 0.13 ± 0.042 0.000 b −0.8703* 0.84 ± 0.196 0.808 − 0.1624
RIS 0.08 ± 0.039 0.000 b −0.9187* 1.10 ± 0.514 0.938 0.1023
CLO 0.20 ± 0.053 0.000 b −0.8039* 0.84 ± 0.232 0.804 −0.1638
Ncl CTRL 1.00 ± 0.183    1.362 12 0.301 1.00 ± 0.420    1.347 12 0.306
HAL 0.35 ± 0.185 0.162 −0.6501 1.64 ± 0.780 0.197 0.6423
RIS 0.74 ± 0.745 0.763 −0.2626 1.36 ± 0.333 0.598 0.3634
CLO 0.63 ± 0.481 0.556 −0.3673 1.14 ± 0.204 0.957 0.1374
Npm1 CTRL 1.00 ± 0.118    4.778 12 0.020 1.00 ± 0.077    17.643 12 0.000
HAL 0.39 ± 0.235 0.000 b −0.6146* 1.65 ± 0.374 0.005 b 0.6497*
RIS 0.49 ± 0.381 0.000 b −0.5104* 0.79 ± 0.059 0.467 −0.2109
CLO 0.52 ± 0.192 0.000 b −0.4820* 0.49 ± 0.264 0.024 b −0.5105*
Plec CTRL 1.00 ± 0.140    44.67 12 0.000 1.00 ± 0.120    27.378 12 0.000
HAL 0.05 ± 0.040 0.000 b −0.9482* 0.59 ± 0.079 0.052 −0.4090
RIS 0.13 ± 0.147 0.000 b −0.8690* 0.99 ± 0.220 1.000 −0.0064
CLO 0.14 ± 0.170 0.000 b −0.8556* 1.93 ± 0.347 0.000 b 0.9341*
Vim CTRL 1.00 ± 0.183    2.002 12 0.167 1.00 ± 0.077    11.822 12 0.001
HAL 1.36 ± 0.549 0.453 0.36478 1.72 ± 0.365 0.796 0.7236
RIS 0.78 ± 0.412 0.769 −0.22386 1.55 ± 0.265 0.891 0.5534
CLO 1.33 ± 0.359 0.521 0.3327 6.07 ± 2.688 0.001 b 5.0720*
  1. Data are presented as mean of expression fold change ± SD. All gene expression experiments were performed in biological duplicates. SD = standard deviation;
  2. MD = mean difference; df = degree of freedom; ANOVA-p = p-value from one-way ANOVA analysis. ap-value = significant value calculated from Dunnett’s C-tests that compare each APD-treated group to control group. b p-value < 0.05. *The mean difference is significant at the 0.05 level in Dunnett’s C-tests