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Table 4 Relative expression of Hist1h4b, Hspa8, Ncl, Npm1, Plec, and Vim genes in C6 and B35 cells after sub-chronic treatment by haloperidol, risperidone, or clozapine

From: Proteomic study revealed antipsychotics-induced nuclear protein regulations in B35 cells are similar to the regulations in C6 cells and rat cortex

 

C6

B35

Gene

Group

Fold Mean ± SD

p-valnea

MD

F

df

ANOVA-p

Fold Mean ± SD

p-valne

MD

F

df

ANOVA-p

Hist1h4b

CTRL

1.00 ± 0.183

  

8.374

12

0.003

1.00 ± 0.199

  

22.561

12

0.000

HAL

1.67 ± 0.091

0.764

0.6748

2.23 ± 0.629

0.198

1.2308

RIS

0.90 ± 0.811

0.999

−0.0961

3.03 ± 0.778

0.024 b

2.0262*

CLO

4.56 ± 2.221

0.003b

3.5581*

6.17 ± 1.554

0.000 b

5.1730*

Hspa8

CTRL

1.00 ± 0.063

  

298.9

12

0.000

1.00 ± 0.196

  

0.690

12

0.575

HAL

0.13 ± 0.042

0.000 b

−0.8703*

0.84 ± 0.196

0.808

− 0.1624

RIS

0.08 ± 0.039

0.000 b

−0.9187*

1.10 ± 0.514

0.938

0.1023

CLO

0.20 ± 0.053

0.000 b

−0.8039*

0.84 ± 0.232

0.804

−0.1638

Ncl

CTRL

1.00 ± 0.183

  

1.362

12

0.301

1.00 ± 0.420

  

1.347

12

0.306

HAL

0.35 ± 0.185

0.162

−0.6501

1.64 ± 0.780

0.197

0.6423

RIS

0.74 ± 0.745

0.763

−0.2626

1.36 ± 0.333

0.598

0.3634

CLO

0.63 ± 0.481

0.556

−0.3673

1.14 ± 0.204

0.957

0.1374

Npm1

CTRL

1.00 ± 0.118

  

4.778

12

0.020

1.00 ± 0.077

  

17.643

12

0.000

HAL

0.39 ± 0.235

0.000 b

−0.6146*

1.65 ± 0.374

0.005 b

0.6497*

RIS

0.49 ± 0.381

0.000 b

−0.5104*

0.79 ± 0.059

0.467

−0.2109

CLO

0.52 ± 0.192

0.000 b

−0.4820*

0.49 ± 0.264

0.024 b

−0.5105*

Plec

CTRL

1.00 ± 0.140

  

44.67

12

0.000

1.00 ± 0.120

  

27.378

12

0.000

HAL

0.05 ± 0.040

0.000 b

−0.9482*

0.59 ± 0.079

0.052

−0.4090

RIS

0.13 ± 0.147

0.000 b

−0.8690*

0.99 ± 0.220

1.000

−0.0064

CLO

0.14 ± 0.170

0.000 b

−0.8556*

1.93 ± 0.347

0.000 b

0.9341*

Vim

CTRL

1.00 ± 0.183

  

2.002

12

0.167

1.00 ± 0.077

  

11.822

12

0.001

HAL

1.36 ± 0.549

0.453

0.36478

1.72 ± 0.365

0.796

0.7236

RIS

0.78 ± 0.412

0.769

−0.22386

1.55 ± 0.265

0.891

0.5534

CLO

1.33 ± 0.359

0.521

0.3327

6.07 ± 2.688

0.001 b

5.0720*

  1. Data are presented as mean of expression fold change ± SD. All gene expression experiments were performed in biological duplicates. SD = standard deviation;
  2. MD = mean difference; df = degree of freedom; ANOVA-p = p-value from one-way ANOVA analysis. ap-value = significant value calculated from Dunnett’s C-tests that compare each APD-treated group to control group. b p-value < 0.05. *The mean difference is significant at the 0.05 level in Dunnett’s C-tests
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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