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Fig. 6 | BMC Pharmacology and Toxicology

Fig. 6

From: Involvement of methylation of MicroRNA-122, −125b and -106b in regulation of Cyclin G1, CAT-1 and STAT3 target genes in isoniazid-induced liver injury

Fig. 6

MiR-122, miR-125b and miR-106b were epigenetically silenced in INH-induced liver injury. (a), (d) and (g) represent the CpG islands of miR-122, miR-125b and miR-106b that were predicted by MethPrimer, respectively. Agarose gel electrophoresis of the PCR products of gene promoter methylation of (b), miR-122, (e) miR-125b and (h) miR-106b. Marker: DNA ladder 50 bp, M: Methylation, U: Unmethylation. DNA methylation at particular CG dinucleotides within the miR-122 gene promoter (c), miR-125b gene promoter (f) and miR-106b gene promoter (i) in liver tissues from INH-administered rats was determined by qMSP. Methylated levels of miR-122, miR-125b and miR-106b in INH-administered rat liver tissues were significantly higher than those in the control rats (*p < 0.05 versus control group)

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