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Fig. 6 | BMC Pharmacology and Toxicology

Fig. 6

From: Mineral trioxide aggregate affects cell viability and induces apoptosis of stem cells from human exfoliated deciduous teeth

Fig. 6

The Bcl-2 family of proteins consists of members that either promote or inhibit apoptosis, and control apoptosis by governing mitochondrial outer membrane permeabilization. The Bcl-2, Bcl-xL and Bax activities were examined using a Western blot assay. The results demonstrated that anti-apoptotic proteins (Bcl-2, Bcl-xL) were significantly decreased compared to the control following 2 days of direct contact with MTA. When the SHEDs were incubated in the environment with the existence of MTA (MTA_IDC), the anti-apoptotic protein BcL-xL was significantly decreased. There was no significant difference between groups in the amount of pro-apoptotic protein (Bax)

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