Table 1 Physical appearance and plasma biochemical profiles before (0 h) and 24 h after administration of puerarin at 1 mg/kg IV and 5 and 10 mg/kg PO
From: Absolute oral bioavailability and disposition kinetics of puerarin in female rats
Parameters | Administration of Puerarin | |||||
|---|---|---|---|---|---|---|
1 mg/kg IV | 5 mg/kg PO | 10 mg/kg PO | ||||
0 h | 24 h | 0 h | 24 h | 0 h | 24 h | |
Physical appearance | Normal | Normal | Normal | Normal | Normal | Normal |
AST (U/L) | 61.67 ± 9.36 | 55.83 ± 2.90 | 57.67 ± 5.10 | 56.00 ± 6.84 | 55.60 ± 7.96 | 57.40 ± 5.12 |
ALT (U/L) | 27.00 ± 26.18 | 11.20 ± 16.22 | 26.33 ± 18.78 | 13.17 ± 17.40 | 25.00 ± 13.92 | 12.17 ± 9.76 |
Creatinine (mg/dL) | 0.20 ± 0.00 | 0.20 ± 0.00 | 0.21 ± 0.02 | 0.21 ± 0.02 | 0.21 ± 0.10 | 0.21 ± 0.08 |