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Table 2 Pharmacokinetic parameters of puerarin and puerarin glucuronide after administration of puerarin at 1 mg/kg IV and 5 and 10 mg/kg PO

From: Absolute oral bioavailability and disposition kinetics of puerarin in female rats

Parameters Administration of Puerarin
1 mg/kg IV 5 mg/kg PO 10 mg/kg PO
Puerarin
 Cmax (μg/L) 621.96 ± 170.72 145.47 ± 84.11 228.00 ± 164.84
 Tmax (h) N/A 0.19 ± 0.09 0.33 ± 0.21
 AUC0-t (μg.h/L) 291.47 ± 108.05 109.45 ± 60.61 204.57 ± 157.47
 AUC0-∞ (μg.h/L) 292.23 ± 108.93 109.58 ± 60.55 212.20 ± 157.50
 Vd (L/kg) 1.16 ± 0.56 101.59 ± 119.57 90.17 ± 18.28
 MRT (h) 0.24 ± 0.06 0.67 ± 0.21 0.88 ± 0.20
 T1/2 (h) 0.21 ± 0.06 0.88 ± 0.49 0.86 ± 56.31
 CL (L/h/kg) 5.43 ± 2.66 65.06 ± 52.75 74.79 ± 0.17
 Absolute bioavailability (%) 100 7.50 7.29
Puerarin glucuronide
 AUC0-t (μg.h/L) 2133.20 73.30 7207.40
 AUCpuerarin glucuronide / AUCpuerarin 7.35 0.67 34.65
  1. Cmax, maximum concentration, Tmax, time to reach maximum concentration, AUC0-t, area under concentration-time curve from time 0 to last observed time, AUC0-∞, area under concentration-time curve from time 0 to infinity, Vd, apparent volume of distribution, MRT, mean resident time, T1/2, half-life, CL, apparent clearance, N/A, not available
  2. Data are presented as mean ± S.D. (n = 4). *p < 0.05 between oral doses