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Table 1 Eligibility criteria

From: The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses

Inclusion criteria
• Patient > 65 years old admitted to an acute medical ward
• Delirium or subsyndromal delirium within the last 48 h
• Signed informed consent from patient or relatives including advance consent for on-going treatment and follow up
Exclusion criteria
• Symptomatic bradycardia, bradycardia due to sick sinus syndrome, second- or third- degree AV-block (if not treated with pacemaker) or any other reason causing HRa < 50 bpmb at time of inclusion
• Symptomatic hypotension or orthostatic hypotension, or a systolic BPc < 120 at the time of inclusion
• Ischemic stroke within the last 3 months or critical peripheral ischemia
• Acute coronary syndrome, unstable or severe coronary heart disease (symptoms at minimal physical activity; NYHAd 3 and 4) and moderate to severe heart failure (NYHA 3 and 4). (Acute coronary syndrome is defined according to international guidelines)
• A diagnosis of polyneuropathy, phaeochromocytoma or renal insufficiency (estimated GFRe< 30 ml/min according to the MDRDf formula)
• Body weight < 45 kg
• Considered as moribund on admission
• Unable to take oral medications
• Current use of tricyclic antidepressants, monoamine reuptake inhibitors or cyclosporine
• Previously included in this study
• Adverse reactions to clonidine or excipients (lactose, saccharose)
• Not speaking or reading Norwegian
• Any other condition as evaluated by the treating physician
• Admitted to the intensive care unit
  1. aHR = heart rate
  2. bbpm = beats per minute
  3. cBP = blood pressure
  4. dNYHA = New York Heart Association Functional Classification
  5. eGFR = glomerular filtration rate
  6. fMDRD = Modification of Diet in Renal Disease formula for estimated GFR