The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses

Table 4 Clonidine concentrations (μg/L) measured at day 1, day 2 and at steady state

Patient	Day 1				Day 2	Steady state Day 4,5 or 6 ^a
	Dose 1 C_max	Dose 2 C_max	Dose 3 C_max	Dose 4 C_max	C₀	C₀	C_max
1	0.32	0.74	0.76		0.65	0.76	0.95
2	0.24	0.43			0.67	^b	^b
3				^c	0.63		0.56
4	0.34	0.59	0.74	0.91	0.71	0.36
5	0.39				0.77		0.61
6	0.27	0.41		^c	0.47	0.41
7	0.46	0.45	0.63		0.74	0.47	0.71
8		0.71		^c	0.69		0.92
9	0.40	0.41	0.52		0.82	0.67	^b
10	0.35	0.85	1.00		0.96		0.77
Median, μg/L	0.35	0.52	0.74	0.91	0.70	0.47	0.74
Range, μg/L	0.24–0.46	0.41–0.85	0.52–1.00		0.47–0.96	0.36–0.76	0.56–0.95
Missing, n	2	2	5	9	0	5	4

All samples were taken 3 h after administration of clonidine, except for C₀ at day 2 and at steady state, taken just before administration of clonidine
^aThe samples at steady state were taken at day 4 (patients 5 and 10), day 5 (patients 3, 8 and 9), and day 6 (patients 1, 4, 6 and 7)
^bThe treatment was halted early (according to the protocol) and complete steady state measurements were not available
^c4th dose not given (according to the protocol as patients were asleep)

ISSN: 2050-6511