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Table 4 Clonidine concentrations (μg/L) measured at day 1, day 2 and at steady state

From: The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses

Patient Day 1 Day 2 Steady state Day 4,5 or 6 a
  Dose 1 Cmax Dose 2 Cmax Dose 3 Cmax Dose 4 Cmax C0 C0 Cmax
1 0.32 0.74 0.76   0.65 0.76 0.95
2 0.24 0.43    0.67 b b
3     c 0.63   0.56
4 0.34 0.59 0.74 0.91 0.71 0.36  
5 0.39     0.77   0.61
6 0.27 0.41   c 0.47 0.41  
7 0.46 0.45 0.63   0.74 0.47 0.71
8   0.71   c 0.69   0.92
9 0.40 0.41 0.52   0.82 0.67 b
10 0.35 0.85 1.00   0.96   0.77
Median, μg/L 0.35 0.52 0.74 0.91 0.70 0.47 0.74
Range, μg/L 0.24–0.46 0.41–0.85 0.52–1.00   0.47–0.96 0.36–0.76 0.56–0.95
Missing, n 2 2 5 9 0 5 4
  1. All samples were taken 3 h after administration of clonidine, except for C0 at day 2 and at steady state, taken just before administration of clonidine
  2. aThe samples at steady state were taken at day 4 (patients 5 and 10), day 5 (patients 3, 8 and 9), and day 6 (patients 1, 4, 6 and 7)
  3. bThe treatment was halted early (according to the protocol) and complete steady state measurements were not available
  4. c4th dose not given (according to the protocol as patients were asleep)