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Table 4 Multivariate linear regression models for determinants of the ratio quinine/3-0H-quinine in 44 prevalent hemodialysis patients. Data are expressed as adjusted r2, beta (β) and significance

From: Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients

  Unadjusted (β, P) (r2 = 0.23) Model 1 (β, P) (r2 = 0.27) Model 2 (β, P) (r2 = 0.27) Model 3 (β, P) (r2 = 0.21)
hsCRP (mg/L) 0.49 (0.001) 0.52 (0.001) 0.54 (0.001) 0.44 (0.05)
Age (years)   0.02 (0.90) −0.002 (0.98) − 0.03 (0.85)
Gender (female)   0.28 (0.04) 0.27 (0.07) 0.30 (0.07)
Diabetes mellitus   −0.13 (0.32) −0.18 (0.22) − 0.14 (0.44)
Vintage (months)   −0.11 (0.42) −0.10 (0.50) − 0.08 (0.62)
Betablockers    0.14 (0.38) 0.12 (0.46)
ACEi/ARBs    −0.21 (0.19) −0.21 (0.21)
Statins    0.18 (0.31) 0.18 (0.31)
PTH (ng/L)     −0.01 (0.93)
Orosomucoid (g/L)     0.14 (0.56)
  1. Abbreviations: hsCRP High sensitivity C reactive protein, ACEi Angiotensin converting enzyme inhibitors, ARBs Angiotensin receptor blockers, PTH Parathyroid hormone
  2. Bold text indicate significance levels