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Table 4 Multivariate linear regression models for determinants of the ratio quinine/3-0H-quinine in 44 prevalent hemodialysis patients. Data are expressed as adjusted r2, beta (β) and significance

From: Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients

 

Unadjusted (β, P) (r2 = 0.23)

Model 1 (β, P) (r2 = 0.27)

Model 2 (β, P) (r2 = 0.27)

Model 3 (β, P) (r2 = 0.21)

hsCRP (mg/L)

0.49 (0.001)

0.52 (0.001)

0.54 (0.001)

0.44 (0.05)

Age (years)

 

0.02 (0.90)

−0.002 (0.98)

− 0.03 (0.85)

Gender (female)

 

0.28 (0.04)

0.27 (0.07)

0.30 (0.07)

Diabetes mellitus

 

−0.13 (0.32)

−0.18 (0.22)

− 0.14 (0.44)

Vintage (months)

 

−0.11 (0.42)

−0.10 (0.50)

− 0.08 (0.62)

Betablockers

  

0.14 (0.38)

0.12 (0.46)

ACEi/ARBs

  

−0.21 (0.19)

−0.21 (0.21)

Statins

  

0.18 (0.31)

0.18 (0.31)

PTH (ng/L)

   

−0.01 (0.93)

Orosomucoid (g/L)

   

0.14 (0.56)

  1. Abbreviations: hsCRP High sensitivity C reactive protein, ACEi Angiotensin converting enzyme inhibitors, ARBs Angiotensin receptor blockers, PTH Parathyroid hormone
  2. Bold text indicate significance levels