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Table 3 Score of sarin-induced degeneration (Fluoro-Jade B positivity) in rat brain and its modulation by different therapeutic approaches

From: The benefit of combinations of oximes for the ability of antidotal treatment to counteract sarin-induced brain damage in rats

 

AMG

CTX

HIPP

HYPOTH

PIRI

TH

score scale

0

1

2

3

4

0

1

2

3

4

0

1

2

3

4

0

1

2

3

4

0

1

2

3

4

0

1

2

3

4

control

8

0

0

0

0

8

0

0

0

0

8

0

0

0

0

8

0

0

0

0

8

0

0

0

0

8

0

0

0

0

GB

2

0

0

1

2

2

0

0

2

1

0

2

0

1

2

2

0

0

3

0

2

0

0

0

3

2

0

0

2

1

GB + A + H

5

0

0

0

1

5

0

0

0

1

5

0

0

0

1

5

0

0

1

0

4

1

0

1

0

5

0

0

1

0

GB + A + H + T

7

0

0

0

0

6

0

1

0

0

5

2

0

0

0

6

0

0

1

0

6

1

0

0

0

6

0

0

1

0

GB + A + H + K

7

1

0

0

0

8

0

0

0

0

8

0

0

0

0

7

0

0

1

0

8

0

0

0

0

8

0

0

0

0

  1. Each number represents a number of animals suffering from particular damage score in the group
  2. Bold: statistically significant compared to control group (p ≤ 0.05)
  3. Bold Italic: statistically significant compared to sarin-poisoned group (p ≤ 0.05)
  4. Abbreviations: A atropine, AMG amygdaloid body, CTX cortex, GB sarin, H oxime HI-6, HIPP hippocampus, HYPOTH hypothalamus, K oxime K203, PIRI piriform cortex, T trimedoxime, TH thalamus