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Table 3 Score of sarin-induced degeneration (Fluoro-Jade B positivity) in rat brain and its modulation by different therapeutic approaches

From: The benefit of combinations of oximes for the ability of antidotal treatment to counteract sarin-induced brain damage in rats

  AMG CTX HIPP HYPOTH PIRI TH
score scale 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4
control 8 0 0 0 0 8 0 0 0 0 8 0 0 0 0 8 0 0 0 0 8 0 0 0 0 8 0 0 0 0
GB 2 0 0 1 2 2 0 0 2 1 0 2 0 1 2 2 0 0 3 0 2 0 0 0 3 2 0 0 2 1
GB + A + H 5 0 0 0 1 5 0 0 0 1 5 0 0 0 1 5 0 0 1 0 4 1 0 1 0 5 0 0 1 0
GB + A + H + T 7 0 0 0 0 6 0 1 0 0 5 2 0 0 0 6 0 0 1 0 6 1 0 0 0 6 0 0 1 0
GB + A + H + K 7 1 0 0 0 8 0 0 0 0 8 0 0 0 0 7 0 0 1 0 8 0 0 0 0 8 0 0 0 0
  1. Each number represents a number of animals suffering from particular damage score in the group
  2. Bold: statistically significant compared to control group (p ≤ 0.05)
  3. Bold Italic: statistically significant compared to sarin-poisoned group (p ≤ 0.05)
  4. Abbreviations: A atropine, AMG amygdaloid body, CTX cortex, GB sarin, H oxime HI-6, HIPP hippocampus, HYPOTH hypothalamus, K oxime K203, PIRI piriform cortex, T trimedoxime, TH thalamus