Table 3 Changes in biochemical parameters among the study groups
Parameters | Linagliptin group (n = 10) | Voglibose group (n = 9) | Control group (n = 7) | P-Value Linagliptin V/S Control | P-Value Voglibose V/S Control | P-Value Voglibose V/S Linagliptin |
|---|---|---|---|---|---|---|
∆HbA1c (%) | −0.2(− 0.6 to 0.3) | −0.8(− 0.9 to − 0.1) | 0.1(− 0.1 to 0.3) | 0.422 | 0.038a | 0.723 |
Mixed Meal Tolerance Test | ||||||
∆AUC C-pep (nmol/L) | −100.5 (− 174.8 to 75.6) | − 80.3 (− 217.6 to 15.0) | −24.9 (− 153.2184.6) | 0.669 | 0.470 | 0.780 |
∆M0 × 10− 8 (1/min) | 1.5(0.2 to 2.7) | 3.5(− 1.4 to 3.9) | 3.7(0.6 to 6.7) | 0.497 | 0.918 | 0.475 |
∆M1 ×10−8 (1/min) | −2.1(−3.7 to 0.2) | −3.3(−6.4 to 2.1) | −3.8(− 6.1 to 0.6) | 0.842 | 1.000 | 0.536 |
Hyperinsulinemic-Euglycemic Clamp Study | ||||||
∆Glucose disposal rate (mg/Kg min) | 0.5(−0.2 to 0.7) | 0.2(0.1 to 0.5) | 0.1(−0.4 to 0.4) | 0.536 | 0.470 | 0.842 |
∆Insulin sensitivity (mg/(Kgmin)/μU/mL) | 0.6(−1.5 to 1.3) | 0.2(−0.9 to 0.9) | 0.2(−0.8 to 0.7) | 0.601 | 0.905 | 0.837 |