Table 3 Gene Ontology (GO) categories of differentially expressed genes (DEGs)
GO ID | Term | Total | Significant | Genes | P-value |
|---|---|---|---|---|---|
GO: 0008202 | steroid metabolic process | 122 | 15 | INSIG1, DHCR7, AKR1C4, SRD5A3, PCSK9, MVD, APOA1, LDLR, MVK, HSD3B2, HSD11B1, STAR, TM7SF2, LSS, SULT1A3 | 6.79E-12 |
GO: 0006695 | cholesterol biosynthetic process | 34 | 7 | INSIG1, DHCR7, MVD, APOA1, MVK, TM7SF2, LSS | 1.08E-07 |
GO: 0008203 | cholesterol metabolic process | 89 | 9 | INSIG1, DHCR7, PCSK9, MVD, APOA1, LDLR, MVK, STAR, TM7SF2 | 4.28E-07 |
GO: 0042542 | response to hydrogen peroxide | 43 | 7 | OLR1, GNAO1, HMOX1, HBA1, HBB, STAR, | 4.43E-07 |
GO: 0006694 | steroid biosynthetic process | 60 | 7 | DHCR7, MVD, MVK, HSD3B2, STAR, TM7SF2, LSS | 3.35E-06 |
GO: 0044281 | small molecule metabolic process | 1410 | 34 | ANGPTL4, PIK3C2B, ABCB1, INSIG1, FHL2, KYNU, ALDH1A1, DHCR7, HMOX1, HBA2, HBA1, PLA2G3, GPAT3, ACSS2, AKR1C4, HBB, SRD5A3, GLUL, SLC25A20, MVD, PDK4, APOA1, G0S2, LDLR, MVK, HSD3B2, GCLC, BGN, SLC2A3, HSD11B1, STAR, TM7SF2, LSS, SULT1A3 | 4.28E-06 |
GO: 0016126 | sterol biosynthetic process | 29 | 5 | INSIG1, DHCR7, MVD, MVK, TM7SF2, | 1.55E-05 |
GO: 0006629 | lipid metabolic process | 490 | 16 | INSIG1, DHCR7, FA2H, PLA2G3, AGPAT9, SRD5A3, PCSK9, MVD, APOA1, LDLR, SLC27A6, MVK, HSD11B1, TM7SF2, LSS, SULT1A3 | 3.91E-05 |
GO: 0007010 | cytoskeleton organization | 7 | 117 | KRT4, NEDD9, THY1, WTIP, RHOU, KRT8, CNN2 | 1.80E-04 |
GO: 0045766 | positive regulation of angiogenesis | 6 | 88 | ANGPTL4, ECM1, HMOX1, GREM1, GATA6, ANXA3 | 2.65E-04 |