Fig. 1

Topical application of tofacitinib and hypochlorous acid, respectively, significantly reduced lesion formation, scratching behaviour and lichenification in NC/Nga mice. a Mice developed moderate lesions 15 days after HDM challenge. A therapeutic intervention with hypochlorous acid or tofacitinib significantly reduced the lesion score and hyperplasia at study day 32; b Scratching bouts steadily increase during repetitive challenge with house dust mite antigen within the first 14 days. Under therapeutic conditions, hypochlorous acid or tofacitinib significantly reduced scratching behaviour. c Back skin thickness was also significantly reduced by treatment with hypochlorous acid or tofacitinib indicating a positive impact on lichenification. n = 8 per group, n = 6 for untreated control), *p < 0.05, **p < 0.01 compared to vehicle treated mice