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Fig. 2 | BMC Pharmacology and Toxicology

Fig. 2

From: Comparison of topical tofacitinib and 0.1% hypochlorous acid in a murine atopic dermatitis model

Fig. 2

Hypochlorous acid and tofacitinib significantly reduced edema and inflammatory cell influx as well as total IgE in serum. a NC/Nga mice were sacrificed on study day 32 and histological samples were taken for the detrermination of edema and inflammatory cell influx. Both treatment options led to significantly reduced edema (a, c) and inflammatory cell influx (b, c) compared to vehicle treated and HDM challenged mice. d Whereas a HDM challenge led to a vast increase of total IgE in vehicle treated mice, this concentration was significantly reduced by topical treatment with HOCl or tofacitnib., n = 8 per group, n = 6 for untreated control), *p < 0.05, **p < 0.01 compared to vehicle treated mice

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