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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Comparison of topical tofacitinib and 0.1% hypochlorous acid in a murine atopic dermatitis model

Fig. 3

Ex vivo response of sensory neurons stimulated with different pruritogens. a The ex vivo response of DRG neurons to IL-31 (1 μg/ml), IL-1β (1 μg/ml), TNFα (1 μg/ml), histamine (1 mmol/l), serotonin (1 mmol/l) and chloroquine (10 μmol/l) and (b) AITC (100 μmol/l) as well as capsaicin (1 μmol/l) were compared to DRG obtained from age matched vehicle treated and house dust mite antigen sensitized and challenged NC/Nga mice. The sensory nerve activation in dorsal root ganglia isolated from hypochlorous acid or tofacitinib treated mice were reduced in response to all stimuli compared to vehicle treated. Absolute number of neurons in brackets, **p < 0.01 compared to vehicle treated mice

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