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Table 1 Cytokine production in back skin of topical application of hypochlorous acid or tofacitinib in NC/Nga mice

From: Comparison of topical tofacitinib and 0.1% hypochlorous acid in a murine atopic dermatitis model

Group Untreated HDM + Vehicle control HDM + Hypochlorous acid HDM + Tofacitinib
IL-1β (pg/mg) 84 ± 25 140 ± 60 83 ± 27 * 41 ± 17 **
IL-4 (pg/mg) 32 ± 18 157 ± 57 87 ± 28 ** 36 ± 19 **†
IL-13 (pg/mg) 183 ± 101 739 ± 451 321 ± 68 * 162 ± 76 **
TARC (pg/mg) 32 ± 16 100 ± 49 53 ± 12 * 27 ± 10 **
TNFα (pg/mg) 98 ± 50 453 ± 230 207 ± 37 ** 108 ± 40 **
TSLP (pg/mg) 69 ± 19 186 ± 96 115 ± 26 ** 76 ± 25 **
  1. Back skin tissue was collected 24 h after last HDM challenge and 1 h after last HOCl or tofacitinib application. Results are expressed as mean ± S.D. (pg/mg protein; n = 8 per group, n = 6 for untreated group)
  2. *: P < 0.05 and **: P < 0.01 (Dunnett’s multiple comparison test) vs. HDM + vehicle control group. †: P < 0.05 (Tukey’s Multiple Comparison Test) HDM + Tofacitinib vs. HDM + Hypochlorous acid group