Comparison of topical tofacitinib and 0.1% hypochlorous acid in a murine atopic dermatitis model

Table 1 Cytokine production in back skin of topical application of hypochlorous acid or tofacitinib in NC/Nga mice

Group	Untreated	HDM + Vehicle control	HDM + Hypochlorous acid	HDM + Tofacitinib
IL-1β (pg/mg)	84 ± 25	140 ± 60	83 ± 27 *	41 ± 17 **
IL-4 (pg/mg)	32 ± 18	157 ± 57	87 ± 28 **	36 ± 19 **†
IL-13 (pg/mg)	183 ± 101	739 ± 451	321 ± 68 *	162 ± 76 **
TARC (pg/mg)	32 ± 16	100 ± 49	53 ± 12 *	27 ± 10 **
TNFα (pg/mg)	98 ± 50	453 ± 230	207 ± 37 **	108 ± 40 **
TSLP (pg/mg)	69 ± 19	186 ± 96	115 ± 26 **	76 ± 25 **

Back skin tissue was collected 24 h after last HDM challenge and 1 h after last HOCl or tofacitinib application. Results are expressed as mean ± S.D. (pg/mg protein; n = 8 per group, n = 6 for untreated group)
*: P < 0.05 and **: P < 0.01 (Dunnett’s multiple comparison test) vs. HDM + vehicle control group. †: P < 0.05 (Tukey’s Multiple Comparison Test) HDM + Tofacitinib vs. HDM + Hypochlorous acid group

ISSN: 2050-6511