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Table 1 Inhibition of P. falciparum Dd2 growth by piperidine analogues at 40 μg/mL

From: Structurally simple synthetic 1, 4-disubstituted piperidines with high selectivity for resistant Plasmodium falciparum

Chemical class Code Substituent Inhibition (%)
Ketones 1 4”-F 83.2
2 3”, 4”-Cl2 82.7
3 4”-Cl 56.6
4 2”-NO2 27.7
5 4”-Br 64.8
6 4”-Me 59.1
Alcohols 7 4”-F 81.3
8 3”, 4”-Cl2 81.7
9 4”-Cl 93.2
10 2”-NO2 79.7
11 4”-Br 85.6
12 4”-Me 83.1
Amines 13 2”-NO2 72.9
14 4”-Br 86.0
  1. Dd2 is a chloroquine-resistant P. falciparum strain