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Table 3 CC50s and selectivity indices of piperidine analogues on LLC-MK2 monkey kidney epithelial cells

From: Structurally simple synthetic 1, 4-disubstituted piperidines with high selectivity for resistant Plasmodium falciparum

Compound codea CC50 (μg/mL) SI on 3D7 SI on Dd2 Mean SI
1 187.5 22.17 32.91 27.54 ± 7.59
2 187.5 43.51 31.37 37.44 ± 8.58
3 62.5 19.45 15.16 17.31 ± 3.0
7 375 93.67 148.34 121.01 ± 38.7
8 93.75 21.14 71.67 46.41 ± 35.7
9 250 149.52 162.97 156.25 ± 9.5
11 187.5 74.49 182.03 128.26 ± 76.1
12 187.5 55.52 67.39 61.46 ± 8.39
13 375 63.71 69.70 66.71 ± 4.24
  1. Chemical classes of compounds:- ketones: 1–3 and alcohols: 712. a Compounds 4, 5, 6 and 10 not tested for cytotoxicity due to low activity in either the primary screen (< 50% inhibition) and or the secondary screen (IC50 > 10 μg/mL). Classification of cytotoxicity: CC50 < 1 μg/mL (high cytotoxicity), CC50 1 μg/mL-10 μg/mL (moderate cytotoxicity), CC50 10 μg/mL-30 μg/mL (mild cytotoxicity) and CC50 > 30 μg/mL (no observable cytotoxicity) [25]. Selectivity Index (SI) = CC50 on LLC-MK2 cells/IC50 on P. falciparum. Mean SI: geometric mean of the Selectivity Indices of the 3D7 and Dd2 parasite strains. Cut-off point for selectivity: SI > 10 (non-toxic); SI ≤ 10 (toxic) [20]