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Fig. 4 | BMC Pharmacology and Toxicology

Fig. 4

From: An inhibitor of 11-β hydroxysteroid dehydrogenase type 1 (PF915275) alleviates nonylphenol-induced hyperadrenalism and adiposity in rat and human cells

Fig. 4

The adrenals from vehicle-, NP-, and NP + PF-treated female rats. a: The 11β-hydroxylase activity was measured in the adrenal cortex using deoxycorticosterone as a substrate. b: The aldosterone synthase activity was measured in the adrenal capsule using corticosterone as a substrate. Values are shown as the means ± S.E.M. c and d: Expression levels of StAR (30 kDa) and PPARα (57 kDa) in the adrenals from vehicle-, NP- and NP + PF-treated female rats were determined by western blot analysis. The representative immunoblot was shown in the upper part, and densitometry for StAR or PPARα normalized to GAPDH was shown in the bottom part. The values are presented as the means ± S.E.M. and are presented as the fold-change relative to the vehicle group. +: p < 0.05, NP group compared with the vehicle group. *, **: p < 0.05, 0.01, NP + PF group compared with the NP group

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