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Table 1 Baseline Characteristics and Predictors of 30-Day Readmission in Patients Receiving Outpatient Parenteral Antimicrobial Therapy

From: Risk factors for readmission in patients discharged with outpatient parenteral antimicrobial therapy: a retrospective cohort study

Parameter Total
(N = 200)
Readmitted
(n = 42)
Not Readmitted
(n = 158)
Univariate analysis
p-value
Age (years) [median (range)] 60 (20–95) 66.5 (29–95) 59 (20–92) < 0.01
Male gender 131 (65.5) 28 (66.7) 103 (65.2) >  0.20
Weight (kg) [median (range)] 79 (31–176) 75.5 (52–147) 80.5 (31–178) 0.08
Assigned primary care provider 131 (65.5) 27 (64.3) 104 (65.8) >  0.20
Insurance >  0.20
 Government-funded 140 (70) 29 (69.0) 111 (70.3)
 Private 56 (28) 12 (28.6) 44 (27.8)
 Self-pay 4 (2) 1 (2.4) 3 (1.9)
Charlson Comorbidity Index [median (IQR)] 2 (1–3) 2 (1–3) 2 (1–3) >  0.20
 Any diabetes 82 (41) 21 (50) 61 (38.6) 0.18
 Immunosuppression 36 (18) 8 (19) 28 (17.7) >  0.20
 Connective tissue disease 35 (17.5) 8 (19) 27 (17.1) >  0.20
 Chronic pulmonary disease 34 (17) 5 (11.9) 29 (18.4) >  0.20
 Peripheral vascular disease 31 (15.5) 6 (14.3) 25 (15.8) >  0.20
 CVA/dementia 20 (10) 7 (16.7) 13 (8.2) 0.14
 Mild liver disease 15 (7.5) 5 (11.9) 10 (6.3) >  0.20
 Congestive heart failure 13 (6.5) 5 (11.9) 8 (5.1) 0.15
 Moderate/severe renal disease 8 (4) 1 (2.4) 7 (4.4) >  0.20
 Hemiplegia 7 (3.5) 0 (0) 7 (4.4) >  0.20
 Myocardial infarction 5 (2.5) 0 (0) 5 (3.2) >  0.20
 Peptic ulcer disease 2 (1) 1 (2.4) 1 (0.6) >  0.20
 Moderate/severe liver disease 2 (1) 1 (2.4) 1 (0.6) >  0.20
Prior admission to MSBI within past 12 months 103 (51.5) 24 (57.1) 79 (50) >  0.20
Prior OPAT within past 12 months 20 (10) 4 (9.5) 16 (10.1) >  0.20
Hospital length-of stay [median (IQR)] 9 (6–15) 11.5 (7–15) 9 (5–15) 0.06
Inpatient service >  0.20
 Medicine 138 (69) 30 (71.4) 108 (68.4)
 Surgery 62 (31) 12 (28.6) 50 (31.6)
ID consult 191 (95.5) 40 (95.2) 151 (95.6) >  0.20
 ID teaching service 100 (52.4) 24 (60) 76 (50.3) >  0.20
 Private ID attending 91 (47.6) 16 (40) 75 (49.7)
ICU admission 48 (24) 13 (31.0) 35 (22.2) >  0.20
Outpatient disposition/OPAT location < 0.01
 Home 120 (60) 16 (38.1) 104 (65.8)
 SNF/SAR 80 (40) 26 (61.9) 54 (34.2)
Post-discharge follow up >  0.20
 ID follow up 129 (64.5) 27 (64.3) 102 (64.6)
 Non-ID follow up 71 (35.5) 15 (35.7) 56 (35.4)
Prior history of MDR organisms 25 (12.5) 5 (11.9) 20 (12.7) >  0.20
 ESBL 10 (35.7) 1 (20) 9 (39.1) >  0.20
 MRSA 15 (53.6) 4 (80) 11 (47.8)
 VRE 3 (10.7) 0 (0) 3 (13.0)
MDR organism isolated during admission 43 (21.5) 8 (19.0) 35 (22.2) >  0.20
 ESBL 17 (37.8) 4 (50) 13 (35.1) >  0.20
 MRSA 23 (51.1) 4 (50) 19 (51.4)
 VRE 5 (11.1) 0 (0) 5 (13.5)
Indication for OPAT
 Osteomyelitis/septic arthritis 71 (35.5) 18 (42.9) 53 (33.5) >  0.20
 Skin and soft tissue infection 47 (23.5) 9 (21.4) 38 (24.1) >  0.20
 Genital/urinary tract infection 35 (17.5) 6 (14.3) 29 (18.4) >  0.20
 Pneumonia 20 (10) 4 (9.5) 16 (10.1) >  0.20
 Intra-abdominal infection 16 (8) 3 (7.1) 13 (8.2) >  0.20
 Bacteremia of unknown source 9 (4.5) 2 (4.8) 7 (4.4) >  0.20
 Prosthetic joint infection 6 (3) 1 (2.4) 5 (3.2) >  0.20
 Endocarditis 5 (2.5) 2 (4.8) 3 (1.9) >  0.20
 CNS infection 4 (2) 0 (0) 4 (2.5) >  0.20
Additional oral antimicrobials 56 (28) 15 (35.7) 41 (25.9) >  0.20
Total number of IV antimicrobials [median (IQR)] 1 (1–1) 1 (1–1) 1 (1–1) >  0.20
Total number of all antimicrobials [median (IQR)] 1 (1–2) 1 (1–2) 1 (1–2) >  0.20
Duration of IV antimicrobial therapy, including inpatient (days) [median (IQR)] 35.5 (15–43) 42 (18–46) 30 (14–43) 0.03
Planned duration of OPAT (days) [median (IQR)] 18 (7–34) 23 (9–34) 16 (7–33.5) >  0.20
PICC line 155 (77.5) 36 (85.7) 119 (75.3) 0.15
  1. All values expressed as n (%) unless otherwise noted
  2. Abbreviations: CNS central nervous system, CVA cerebrovascular accident, ESBL extended-spectrum beta-lactamase, ICU intensive care unit, ID Infectious Diseases, IQR interquartile range, IV intravenous, MDR multidrug resistant, MRSA methicillin-resistant Staphylococcus aureus, MSBI Mount Sinai Beth Israel, OPAT outpatient parenteral antimicrobial therapy, PICC peripherally inserted central catheter, SAR subacute rehabilitation, SD standard deviation, SNF skilled nursing facility, VRE vancomycin-resistant enterococcus