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Table 4 Factors associated with survivability after ADR events using simple logistic and multiple regression

From: Survivability of hospitalized chronic kidney disease (CKD) patients with moderate to severe estimated glomerular filtration rate (eGFR) after experiencing adverse drug reactions (ADRs) in a public healthcare center: a retrospective 3 year study

Variables Survived N(%) Died N(%) Crude OR (95% CI) p -valuea Adj. OR (95% CI) p -valueb
Age category
  ≤ 49 years 34 (82.9%) 7 (17.1%) 1.00(ref.)   0.888 1.00(ref.)   0.490
 50–59 years 32 (80.0%) 8 (20.0%) 1.21 (0.40, 3.73) 0.735 2.05 (0.57,7.34)  
  ≥ 60 years 66 (83.5%) 13 (16.5%) 0.96 (0.35, 2.62) 0.931 1.14 (0.35, 3.66)  
Gender
 Male 77 (83.7%) 15 (16.3%) 1.00(ref.)   0.644 1.00(ref.)   0.829
 Female 55 (80.9%) 13 (19.1%) 1.21 (0.54,2.75)   0.88 (0.28,2.75)  
Ethnicity
 Malay 44 (84.6%) 8 (15.4%) 1.00(ref.)   0.544 1.00(ref.)   0.108
 Chinese 57 (83.8%) 11 (16.2%) 1.06 (0.39,2.86) 0.906 0.70 (0.20, 2.44)  
 Indian 29 (76.3%) 9 (23.7%) 1.71 (0.59,4.93) 0.324 2.59 (0.77,8.72)  
BMI category
 Underweight 14 (82.4%) 3 (17.6%) 1.00(ref.)   0.917 1.00(ref.)   0.825
 Normal 58 (84.1%) 11 (15.9%) 0.89 (0.22,3.60) 0.865 0.82 (0.17, 4.05)  
 Overweight 43 (79.6%) 11 (20.4%) 1.19 (0.29,4.90) 0.806 1.33 (0.27, 6.56)  
 Obese 17 (85.0%) 3 (15.0%) 0.82 (0.14,4.74) 0.828 1.34 (0.18, 9.71)  
Smoking
 No 98 (82.4%) 21 (17.6%) 1.00(ref.)   0.934 1.00(ref.)   0.800
 Yes 34 (82.9%) 7 (17.1%) 0.96 (0.38,2.46)   1.19 (0.32, 4.47)  
Alcohol consumption
 No 113 (82.5%) 24 (17.5%) 1.00(ref.)   0.988 1.00(ref.)   0.943
 Yes 19 (82.6%) 4 (17.4%) 0.99 (0.31, 3.18)   1.06 (0.21, 5.46)  
Renal replacement therapy
 Hemodialysis 52 (85.2%) 9 (14.8%) 1.00(ref.)   0.751 1.00(ref.)   0.023*
 Peritoneal dialysis 10 (83.3%) 2 (16.7%) 1.16 (0.22,6.17) 0.866 1.21 (0.21, 6.940)  
 Conservative management 70 (80.5%) 17 (19.5%) 1.40 (0.58,3.40) 0.453 5.90 (1.63,21.34)  
Renal function
 30–59 mL/min/1.73m2 46 (93.9%) 3 (6.1%) 1.00(ref.)   0.062 1.00(ref.)   0.002*
 15–29 mL/min/1.73m2 22 (75.9%) 7 (24.1%) 4.88 (1.15,20.69) 0.032 8.90 (1.76, 44.94)  
  < 15 mL/min/1.73m2 64 (78.0%) 18 (22.0%) 4.31 (1.20,15.51) 0.025 22.37 (3.99,125.31)  
  1. Note: aSimple Logistic Regression;
  2. bMultiple Logistic Regression;
  3. Crude OR = Crude Odds Ratio;
  4. Adj. OR = Adjusted Odds Ratio;
  5. 95% CI = 95% confidence interval
  6. *p value< 0.05