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Table 5 Lethal dose ratios for the examples fitted to the probit-log(dose) regression models calculated by the ML procedure (Excel), Polo-Plus and SPSS

From: Comparing lethal dose ratios using probit regression with arbitrary slopes

Interested levels (π)

Comparison

Lethal ratio (95%CL)

RMP (95%CL)a

Excel

Polo-Plus

SPSS2b

10

Rotenone/Deguelin

0.745 (0.496, 1.119)

0.745 (0.494, 1.122)

 

Rotenone/Mixture

1.211 (0.812, 1.808)

1.211 (0.805, 1.824)

 

Fairfax/Scheafer

1.006 (0.645, 1.569)

1.006 (0.642, 1.577)

 

Fairfax / Pixley c

0.211 (0.128, 0.346)

0.221 (0.132, 0.369)

 

BugRes / BugLab

0.697 (0.376, 1.293)

0.520 (0.238, 1.138)

 

50

Rotenone/Deguelin

0.489 (0.398, 0.602)

0.489 (0.397, 0.603)

0.455 (0.173, 0.793)

Rotenone/Mixture

0.761 (0.623, 0.929)

0.761 (0.621, 0.933)

0.710 (0.440, 1.005)

Fairfax/Scheafer

1.097 (0.905, 1.329)

1.097 (0.902, 1.335)

1.106 (0.811, 1.550)

Fairfax / Pixley c

0.244 (0.198, 0.301)

0.250 (0.201, 0.311)

0.261 (0.045, 0.571)

BugRes / BugLab

2.254 (1.753, 2.898)

2.030 (1.478, 2.787)

3.898 (0.455, 4701.677)

90

Rotenone/Deguelin

0.321 (0.243, 0.425)

0.321 (0.241, 0.428)

 

Rotenone/Mixture

0.478 (0.357, 0.642)

0.478 (0.354, 0.646)

 

Fairfax/Scheafer

1.196 (0.819, 1.747)

1.196 (0.814, 1.758)

 

Fairfax / Pixley c

0.282 (0.189, 0.422)

0.283 (0.186, 0.430)

 

BugRes / BugLab

7.288 (4.014, 13.232)

7.926 (4.077, 15.412)

 

99

Rotenone/Deguelin

0.228 (0.142, 0.366)

0.228 (0.140, 0.371)

 

Rotenone/Mixture

0.328 (0.199, 0.539)

0.328 (0.197, 0.546)

 

Fairfax/Scheafer

1.284 (0.667, 2.469)

1.284 (0.661, 2.493)

 

Fairfax / Pixley

0.318 (0.158, 0.642)

0.313 (0.151, 0.651)

 

BugRes / BugLab

18.968 (6.820, 52.753)

24.064 (7.520, 77.007)

 
  1. aRMP, relative median potency. We did not show the RMP of SPSS by inputting C methods because of different C values in the two samples
  2. bSPSS calculates the corrected p from the data. We did not calculate RMP with SPSS by inputting C methods because of different C values in the two samples
  3. cBold items indicated the data sets included natural responses in the control group