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Table 2 Medications and changes of key laboratory abnormalities

From: The critical interaction between valproate sodium and warfarin: case report and review

 

Premorbidity

Day 1

Day 2

Day 3

Day 4

Day 5

Discharge

Warfarin PO

1.875 mg QD

1.875 mg QD

1.875 mg QD

paused

1.25 mg QD

1.875 mg QD

1.875 mg QD

Diazepam IV

 

10 mg

     

LEV PO

500 mg QD

500 mg BID

500 mg BID

500 mg BID

500 mg BID

500 mg BID

500 mg BID

Valproate sodium IV

 

1200 mg

Discontinuation at accumulated dose of 2200 mg

    

Vitamin K1 IV

   

5 mg

   

Other medications

isosorbide mononitrate sustained release tablets 40 mg PO QD, succinate metoprolol tablets 12.5 mg PO BID

INR (time)

 

2.02 (10:51)

2.04 (09:30)

8.26 (10:56)

5.52 (16:11)

5.32 (22:41)

2.16 (06:18)

2.07 (09:34)

2.43 (10:01)

PT (seconds)

 

22.50

22.70

86.90

63.00

60.80

24.20

23.30

27.50

Creatinine (μmol/l)

 

75

 

126

79

64

58

Albumin (g/L)

  

38.50

   

31.60

  1. LEV levetiracetam, IV intravenous, INR international normalized ratio, PT prothrombin time, QD once daily, BID twice daily, PO by mouth