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Table 2 Medications and changes of key laboratory abnormalities

From: The critical interaction between valproate sodium and warfarin: case report and review

  Premorbidity Day 1 Day 2 Day 3 Day 4 Day 5 Discharge
Warfarin PO 1.875 mg QD 1.875 mg QD 1.875 mg QD paused 1.25 mg QD 1.875 mg QD 1.875 mg QD
Diazepam IV   10 mg      
LEV PO 500 mg QD 500 mg BID 500 mg BID 500 mg BID 500 mg BID 500 mg BID 500 mg BID
Valproate sodium IV   1200 mg
Discontinuation at accumulated dose of 2200 mg
    
Vitamin K1 IV     5 mg    
Other medications isosorbide mononitrate sustained release tablets 40 mg PO QD, succinate metoprolol tablets 12.5 mg PO BID
INR (time)   2.02 (10:51) 2.04 (09:30) 8.26 (10:56)
5.52 (16:11)
5.32 (22:41)
2.16 (06:18) 2.07 (09:34) 2.43 (10:01)
PT (seconds)   22.50 22.70 86.90
63.00
60.80
24.20 23.30 27.50
Creatinine (μmol/l)   75   126 79 64 58
Albumin (g/L)    38.50     31.60
  1. LEV levetiracetam, IV intravenous, INR international normalized ratio, PT prothrombin time, QD once daily, BID twice daily, PO by mouth