Toxicological evaluation of therapeutic and supra-therapeutic doses of Cellgevity® on reproductive function and biochemical indices in Wistar rats

Table 2 Effects of therapeutic and supra-therapeutic doses of CGV on antioxidant indices in rat ovaries

Treatment	GSH	SOD	CAT	GST	MDA
Control	21.94 ± 1.77	17.9 ± 0.13	12.47 ± 1.46	6.3 ± 0.05	1.13 ± 0.02
14.3	59.68 ± 3.77^** (− 172)	13.21 ± 1.06 (26.2)	16.48 ± 2.58^* (− 32.2)	3.95 ± 1.15 (37.3)	1.13 ± 0.22 (0.0)
28.6	61.72 ± 5.19^** (− 181.3)	13.78 ± 2.17 (23)	16.89 ± 1.04^* (− 35.4)	3.98 ± 1.49 (36.8)	0.93 ± 0.13 (17.7)
1000	18.31 ± 1.00 (16.5)	13.9 ± 0.12 (22.3)	12.91 ± 0.67 (− 3.5)	3.7 ± 0.03 (41.3)	1.5 ± 0.04^* (− 32.7)
2000	21.62 ± 1.96 (1.5)	12.8 ± 0.12 (28.5)	12.54 ± 0.41 (− 0.6)	3.4 ± 0.03 (46.0)	1.45 ± 0.04^*(− 28.3)
3000	20.37 ± 1.51 (7.2)	16.0 ± 0.04 (10.6)	13.41 ± 0.47 (− 7.5)	4.2 ± 0.01 (33.3)	1.57 ± 0.02^*(− 38.9)

Data are expressed as mean ± SEM. n = 6.^*p < 0.05 or ^**p < 0.001 when compared with control group. Values in parenthesis represent % change; (−) increase; (+) decrease. Control (Distilled Water, 10 ml/kg); Superoxide dismutase; GSH Reduced glutathione (μmol/mg protein), SOD Superoxide dismutase (μmol/min/mg protein), Catalase (μmol/ml/mg protein), GST Glutathione S-transferase (μmol/ml/mg protein), MDA Malondialdehyde (nmol/mg protein)

ISSN: 2050-6511