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Table 4 MTHFR (C677T and A1298C) gene polymorphisms with its relative frequencies in poor seizures controlled and seizure controlled patients at 3rd month of carbamazepine monotherapy

From: Epilepsy control with carbamazepine monotherapy from a genetic perspective

N = 71 Carbamazepine non-responsive patients (n = 46) Carbamazepine responsive patients (n = 25)
Variables Total Total
Number (%) 46 (65) 25 (35)
Genotypes
 677CC 14 16
 677CT 21 4
 677TT 11 5
 1298AA 13 17
 1298 AC 22 5
 1298CC 11 3
  1. MTHFR (C677T) Gene
  2. Heterozygous (677CT) were more likely frequent in carbamazepine resistant patients compared to carbamazepine responsive patients in Pakhtun population of KP (χ2 = 6.75, P = 0.009)*) comparing total patients of carbamazepine resistant VS total patients who are responsive to carbamazepine therapy.
  3. However, homozygous mutant (677TT) genotypes were less likely associated with carbamazepine therapy resistant patients as compared to carbamazepine responsive patients (χ2 = 1.5, P = 0.026)
  4. MTHFR (A1298C) Gene
  5. Heterozygous (1298 AC) genotypes were more likely frequent in carbamazepine resistant patients compared to carbamazepine responsive patients (χ2 = 7.2, P = 0.007**) comparing total patients of carbamazepine resistant VS total patients who are responsive to carbamazepine therapy.
  6. However, homozygous mutant (1298CC) genotypes were less likely associated with carbamazepine therapy resistant patients as compared to carbamazepine responsive patients (χ2 = 3.5, P = 0.05).