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Table 2 Demographics and clinical characteristics of trimethoprim-sulfamethoxazole-induced severe reactions in the literature

From: Trimethoprim-sulfamethoxazole induced circulatory shock in a human immunodeficiency virus uninfected patient: a case report and review

Author, year Age (yrs.) HIV Status CD4+ (cells/mm3) TMP-SMX Regimen Time of Onset Fever (°C) Hypotension (mmHg) Rash Hypoxemia Pulm. Infiltrates Acute Kidney Injury Elevated liver enzymes
Johnson et al. 1990 28 AIDS NS DS tablet Several Hours 39.0 SBP 90 +
38 HIV (+) NS DS tablet Several Hours 39.0 SBP 75
Kelly et al. 1992 46 AIDS NS DS tablet < 4 h 39.8 60/0 + + + +
34 AIDS NS DS tablet < 1 h 39.4 80/40 + + + + +
22 AIDS NS DS tablet 4 h 40.2 70/0 + +
31 AIDS NS SS tablet 1 h 40.2 + + NS NS NS NS
46 AIDS NS ? IV dose Several minutes 40.0 60/40 + + + NS NS
28 AIDS NS ? PO dose 30 min 40.0 70/40 + + + NS NS
34 AIDS NS DS tablet 30 min 41.0 60/28 + + + + NS
23 AIDS NS ? PO dose “quickly” 40.5 82/0 + + + NS NS
28 HIV (+) NS DS tablet < 2 h 39.0 65/0 + + + NS NS
38 HIV (+) NS NS NS 39.0 75/0 + NS + + +
Nguyen et al. 1993 37 HIV (+) 190 DS tablet 2 h 40.0 84/30 +
Caumes et al. 1996 48 AIDS 366 ? PO dose 20 min + + +
Scourfield et al. 2010 38 HIV (+) 13 ? PO dose 1 h 40.0 75/34 NS + NS NS
Persichino et al. 2016 36 HIV (+) 24 DS tablet 1 h 40.1 72/23 +
Abbas et al. 2017 85 HIV (−) NS ? PO dose 5 h + NS +
85 HIV (−) NS ? PO dose NS NS NS +
Presented Case 42 HIV (−) 64 DS tablet < 2 h 39.1 88/63 + +
  1. -: Negative Finding; +: Positive Finding; NS Not Stated, SBP Systolic Blood Pressure