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Table 2 Demographics and clinical characteristics of trimethoprim-sulfamethoxazole-induced severe reactions in the literature

From: Trimethoprim-sulfamethoxazole induced circulatory shock in a human immunodeficiency virus uninfected patient: a case report and review

Author, year

Age (yrs.)

HIV Status

CD4+ (cells/mm3)

TMP-SMX Regimen

Time of Onset

Fever (°C)

Hypotension (mmHg)

Rash

Hypoxemia

Pulm. Infiltrates

Acute Kidney Injury

Elevated liver enzymes

Johnson et al. 1990

28

AIDS

NS

DS tablet

Several Hours

39.0

SBP 90

+

38

HIV (+)

NS

DS tablet

Several Hours

39.0

SBP 75

Kelly et al. 1992

46

AIDS

NS

DS tablet

< 4 h

39.8

60/0

+

+

+

+

34

AIDS

NS

DS tablet

< 1 h

39.4

80/40

+

+

+

+

+

22

AIDS

NS

DS tablet

4 h

40.2

70/0

+

+

31

AIDS

NS

SS tablet

1 h

40.2

+

+

NS

NS

NS

NS

46

AIDS

NS

? IV dose

Several minutes

40.0

60/40

+

+

+

NS

NS

28

AIDS

NS

? PO dose

30 min

40.0

70/40

+

+

+

NS

NS

34

AIDS

NS

DS tablet

30 min

41.0

60/28

+

+

+

+

NS

23

AIDS

NS

? PO dose

“quickly”

40.5

82/0

+

+

+

NS

NS

28

HIV (+)

NS

DS tablet

< 2 h

39.0

65/0

+

+

+

NS

NS

38

HIV (+)

NS

NS

NS

39.0

75/0

+

NS

+

+

+

Nguyen et al. 1993

37

HIV (+)

190

DS tablet

2 h

40.0

84/30

+

Caumes et al. 1996

48

AIDS

366

? PO dose

20 min

+

+

+

Scourfield et al. 2010

38

HIV (+)

13

? PO dose

1 h

40.0

75/34

NS

+

NS

NS

Persichino et al. 2016

36

HIV (+)

24

DS tablet

1 h

40.1

72/23

+

Abbas et al. 2017

85

HIV (−)

NS

? PO dose

5 h

+

NS

+

85

HIV (−)

NS

? PO dose

NS

NS

NS

+

Presented Case

42

HIV (−)

64

DS tablet

< 2 h

39.1

88/63

+

+

  1. -: Negative Finding; +: Positive Finding; NS Not Stated, SBP Systolic Blood Pressure