PK parameter | C57BL/6 mice | Prairie dogs |
---|---|---|
IV Dose (mg/kg) | 10 | 10 |
No. of animals | 3a | 5 |
T1/2 (h) | 0.88 | 2.8 ± 1 |
MRT (h) | 0.77 | 2.02 ± 0.24 |
CL (ml/hr./kg) | 2212 | 821 ± 179 |
Vss (ml/kg) | 1697 | 1666 ± 464 |
AUC0-inf (ng.hr./ml) | 4522 | 12,558 ± 2189 |
Oral Dose (mg/kg) | 10 | 30 |
No. of animals | 3a | 4 |
Tmax (h) | 1 | 3 ± 1.15 |
Cmax (ng/ml) | 1468 | 1677 ± 834 |
Apparent T1/2 (h) | 0.84 | 2.2 ± 0.6 |
AUC0-inf (ng.hr./ml) | 4852 | 8092 ± 3012 |
Bioavailability (%) | 107 | 22 |