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Table 3 CL and Vss prediction of nilotinib in prairie dogs

From: Preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents

S. No.

Method

Predicted Value

Fold Error

CL(L/hr./kg)

 1

SA (CL vs. BW)

0.42

2.24

 2

SA (CL/fup vs. BW)

0.47

2.5

 3

ROE (CL × BrW vs. BW)

0.44

2.32

Vss (L/kg)

 1

SA (Vss vs. BW)

1.45

1.25

 2

SA (Vss/fup vs. BW)

1.62

1.40

  1. SA simple allometry, ROE rule of exponents, SSS single species scaling
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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