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Table 3 CL and Vss prediction of nilotinib in prairie dogs

From: Preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents

S. No. Method Predicted Value Fold Error
CL(L/hr./kg)
 1 SA (CL vs. BW) 0.42 2.24
 2 SA (CL/fup vs. BW) 0.47 2.5
 3 ROE (CL × BrW vs. BW) 0.44 2.32
Vss (L/kg)
 1 SA (Vss vs. BW) 1.45 1.25
 2 SA (Vss/fup vs. BW) 1.62 1.40
  1. SA simple allometry, ROE rule of exponents, SSS single species scaling