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Table 4 CL and Vss prediction of imatinib in prairie dogs

From: Preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents

S. No.

Method

Value

Fold error

CL (L/hr./kg)

 1

SA (CL vs. BW)

1.41

1.78

 2

SA (CL/fup vs. BW)

0.85

1.07

 3

ROE (CL × MLP vs. BW)

1.78

2.24

Vss (L/kg)

 1

SA (Vss vs. BW)

7.18

4.43

 2

SA (Vss/fup vs. BW)

3.65

2.25

  1. SA simple allometry, ROE rule of exponents, SSS single species scaling
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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