Fig. 1

a Plasma trough concentration of isavuconazole after intravenous (IV) or oral dosing (arrows indicate times of pharmacokinetic study days). In parallel, cerebral MRIs on Day 21 of fever and after 6 months of antifungal treatment showing regression of a ring-enhanced cerebral lesion (from 5.5 cm in diameter to 3.2 cm) in the right frontal parietal region. b Pharmacokinetic profiles of isavuconazole. Plasma concentrations of isavuconazole during 24 h following dosing at day 7 (90 mg/d, IV), and during 12 h following dosing day 24 (90 mg bid, IV) and day 44 (100 mg bid, oral). (bid, twice a day; IV, intravenous; L-AmB, liposomal amphotericin B; po, per os)