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Table 1 Characteristics of studies describing the resistance profile of clinical relevant bacterial isolates against ciprofloxacin

From: Resistance profile of clinically relevant bacterial isolates against fluoroquinolone in Ethiopia: a systematic review and meta-analysis

Study ID Quality score Year (pub) Study Area Study Design Population (Clinical features) Source of sample Bacterial Category Type of isolates Number of isolates No of resistant (%)
Abamecha et al. [35] 8.5 2015 JUSH CS Hospitalized patients Stool Gram + Ve E. faecalis 114 57 50.00
Abera et al. [51] 9 2016 FHRH CS In/outpatients with infections Urine and Blood Gram -Ve E. coli 122 49 40.16
K. Pneumoniae 49 28 57.14
P. mirabilis 29 10 34.48
Alemseged et al. [43] 8 2015 ARH and MHC, Mekele CS Pregnant women Vaginal swabs Gram + Ve GBS 19 1 5.26
Ali et al. [78] 8.5 2016 Gambella hospital CS STI suspected patients Urethral or endo-cervical swabs Gram -Ve N. gonorrhoeae 21 6 28.57
Ameya et al. [36] 8 2018 Arba Minch province CS Under five children (diarrhea) Stool Gram -Ve Salmonela 21 0 0.00
Shigella 8 0 0.00
Denboba et al. [46] 7.5 2016 DRHRL CS (R) Patients with Otitis media Ear discharges Gram + Ve S. auerus 102 1 0.98
Gram -Ve Pseudomonas spp 134 13 9.70
Proteus spp 114 8 7.02
K. pneumoniae 9 0 0.00
E. coli 69 6 8.70
Assefa et al. [55] 8 2015 UoGH CS Dacryocystitis patients Nasolacrim al discharge Gram + Ve S. auerus 6 0 0.00
CoNS 9 4 44.44
Ayelign et al. [20] 8.5 2018 UoGH CS Pediatric patients with UTI Urine specimens Gram + Ve S. auerus 8 0 0.00
Gram -Ve E. coli 45 8 17.78
Pseudomonas spp 8 1 12.50
Bekele et al. [21] 7 2015 JUSH CS Catheterized patients Urine samples (Catheter) Gram -Ve Pseudomonas spp 36 0 0.00
Bitew et al. [22] 8.5 2017 Arsho AML, AA CS Patients with UTI Urine Gram + Ve S. auerus 9 3 33.33
E. faecalis 14 1 7.14
Gram -Ve E. coli 135 68 50.37
K. pneumoniae 18 3 16.67
Deribe et al. [23] 6.5 2017 Bahir Dar Regional HRLC CS (R) Patient with presumptive UTI Urine Gram + Ve S. auerus 9 3 33.33
Gram -Ve E. coli 64 41 64.06
K. pneumoniae 19 4 21.05
  Pseudomonas spp 8 0 0.00
Proteus spp 6 4 66.67
Dereje et al. [24] 8.5 2017 Hamlin fistula hospital, AA CS Fistula patients (UTI) Urine Gram -Ve E. coli 65 37 56.92
K. pneumoniae 14 11 78.57
Proteus spp 31 14 45.16
Derese et al. [25] 9.5 2016 DRH CS Pregnant women with UTI Urine Gram + Ve CoNS 5 1 20.00
Gram -Ve E. coli 9 1 11.11
Dessie et al. [50] 9 2016 Selected referral hospitals, AA CS Surgical site infected patients Wound swabs Gram + Ve S. auerus 19 3 15.79
Gram -Ve E. coli 24 16 66.67
K. pneumoniae 10 2 20.00
Pseudomonas spp 6 2 33.33
Eshetie et al. [26] 9.5 2015 UoGH CS Patients with UTI Urine Gram -Ve E. coli 104 1 0.96
K. pneumoniae 28 3 10.71
Gebrekidan et al. [37] 7.5 2015 Mekele hospital CS Outpatients with acute diarrhea Stool Gram -Ve Shigella 15 1 6.67
Teweldemedihin [40] 8 2017 Quiha Ophthalmic Hospital CS Patients with ocular infections Ocular specimens Gram + Ve S. auerus 40 5 12.50
CoNS 31 3 9.68
E. faecalis 8 1 12.50
K. Pneumonia 7 1 14.29
Pseudomonas spp 21 4 19.05
E. coli 15 1 6.67
Getahun et al. [41] 10 2017 UoGH CS Patients with ocular infections Ocular samples/ external Gram + Ve S. auerus 96 7 7.29
CoNS 64 7 10.94
Gram -2015Ve E. coli 6 1 16.67
K. pneumoniae 9 2 22.22
Gezmu et al. [27] 6 2016 Arba Minch Hospital CS Patients with UTI Urine Gram + Ve S. auerus 10 3 30.00
Gram -Ve E. coli 20 4 20.00
K. pneumoniae 8 2 25.00
Hailu et al. [34] 8 2016 Bahir Dar Reg HRLC CS Febrile patients Blood Gram + Ve S. auerus 50 10 20.00
CoNS 35 3 8.57
Gram -Ve E. coli 19 5 26.32
K. pneumoniae 35 10 28.57
Pseudomonas spp 15 2 13.33
Hailu et al. [49] 7.5 2016 Bahir Dar Regional HRLC CS (R) Patiets with infected wounds wound swab Gram + Ve S. auerus 67 5 7.46
S. pyogens 20 1 5.00
Gram -Ve E. coli 33 15 45.45
K. Pneumonia 20 4 20.00
Pseudomonas spp 26 5 19.23
Proteus spp 22 5 22.73
Hailu et al. [47] 7.5 2016 Bahir Dar Regional HRLC CS (R) Patients with ear infections Ear discharges Gram + Ve S. auerus 78 0 0.00
CoNS 34 0 0.00
S .pneumonia 7 0 0.00
Gram -Ve E. coli 7 1 14.29
K. Pneumoniae 10 1 10.00
Pseudomonas spp 88 7 7.95
Proteus spp 65 3 4.62
Kumalo et al. [30] 7 2016 JUSH CS Sepsis patients Blood Gram + Ve S. auerus 6 1 16.67
Lamboro et al. [38] 8.5 2016 JUSH CS Outpatients with diarrhea Stool Gram -Ve Salmonella 19 0 0.00
Mengist et al. [44] 7 2016 JUSH CS Pregnant women Anorectal and Vaginal Gram + Ve GBS 31 3 9.68
Mitku [28] 6.5 2017 DRHRL CS (R) Outpatients with UTI Urine Gram -Ve E. coli 25 2 8.00
K. Pneumoniae 7 1 14.29
Proteus spp 6 1 16.67
Mulu et al. [52] 8.5 2017 DMRH CS (R) Any patients with infection Non specific/ all types Gram + Ve S. auerus 13 6 46.15
Gram -Ve E. coli 22 4 18.18
Pseudomonas spp 17 6 35.29
Salmonella 16 4 25.00
N. gonorrheae 8 13 61.53
Negussie et al. [31] 6.5 2015 Selected hospitals, AA CS Septicemia suspected children Blood Gram + Ve S. auerus 13 4 30.77
CoNS 11 2 18.18
Gram -Ve K. pneumoniae 9 4 44.44
Nigussie and Amsalu [29] 7.5 201 HURH CS Diabetic patients Urine Gram + Ve S. auerus 6 3 50.00
CoNS 8 4 50.00
Gram -Ve E. coli 11 2 18.18
Regassa et al. [53] 8 2015 JUSH CS CAP paients Sputum and Blood Gram + Ve S. auerus 16 5 31.25
Gram -Ve Pseudomonas spp 10 2 20.00
K. pneumoniae 8 0 0.00
Sahile et al. [54] 6 2016 JUSH CS Patients with surgical and gynecologic wound Urine and wound swab Gram + Ve S. auerus 22 13 59.09
CoNS 21 16 76.19
Gram -Ve E. coli 9 4 44.44
Pseudomonas spp 8 4 50.00
Proteus spp 7 3 42.86
Shiferaw et al. [42] 8.5 2015 BoruMeda Hospital CS Patients with ex-ocular infections External ocular specimens Gram + Ve S. auerus 21 2 9.52
CoNS 51 4 7.84
S. pneumoniae 10 2 20.00
S. pyogens 6 0 0.00
Terfasa and Jida [39] 8 2018 Nekemte referral hospital CS Diarrheal patients Stool Gram -Ve Salmonella 30 2 6.67
Shigella 9 0 0.00
Wasihun et al. [32] 8 2015 Mekelle hospital CS Febrile patients Blood Gram + Ve S. auerus 54 21 38.89
CoNS 44 11 25.00
Gram -Ve E. coli 16 1 6.25
Salmonela 8 4 50.00
Wasihun et al. [33] 8.5 2015 Mekelle hospial CS Febrile patients Blood Gram + Ve S. auerus 41 18 43.90
CoNS 39 10 25.64
S. pyogens 6 1 16.67
Gram -Ve E. coli 12 1 8.33
Salmonella 8 1 12.50
Wasihun and Zemene [48] 8 2015 ARH CS Patients with otitis media Ear discharges Gram + Ve S. auerus 46 10 21.74
CoNS 17 9 52.94
S. pneumonia 15 3 20.00
S. pyogens 16 3 18.75
Gram -Ve Proteus spp 39 0 0.00
Pseudomonas spp 27 10 37.04
K. pneumoniae 18 2 11.11
E. coli 6 1 16.67
Mulu et al. [45] 7 2015 FHRH CS Women with vaginal infections Vaginal swabs Gram + Ve S. auerus 15 3 20.00
Gram -Ve E. coli 6 2 33.33
Pseudomonas spp 7 0 0.00
  1. Abbreviations: CoNS coagulase negative Staphylococci, CS cross-sectional, R retrospective, HURH Hawassa University Referral Hospital, UoGH University of Gondar Hospital; JUSH Jimma University Specialized Hospital, DRHRL Dessie Regional Health Research laboratory, STI sexually transmitted diseases, UTI Urinary tract infections, ARH Ayder Referral Hospital, GBS Group B Streptococci, FHRH Felege Hiwot Referral Hospital, DMRH Debre Markos Referral Hospital, CAP Community Acquired Pneumonia