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Table 2 Comparison of the apparent absorptions of five SQV SDNs to that of standard SQV across differentiated Caco-2 monolayers after 1 hour of incubation (n=5)

From: Enhancement of saquinavir absorption and accumulation through the formation of solid drug nanoparticles

Sample

Apparent absorption = PappAP-BL/ PappBL-AP

SQV

SQV SDN 05

SQV SDN 06

SQV SDN 07

SQV SDN 09

SQV SDN 13

1

0.5

1.8

0.4

0.3

0.6

0.1

2

0.2

0.2

0.4

0.1

0.2

0.1

3

0.2

0.4

0.5

0.3

0.3

0.0

4

1.7

0.8

0.4

1.6

0.5

0.0

5

0.9

1.3

1.5

0.8

0.8

0.7

Mean

0.7

0.9

0.7

0.6

0.5

0.2

STDEV

0.6

0.7

0.5

0.6

0.2

0.3

  

p = 0.61

p > 0.99

p = 0.88

p = 0.50

p = 0.06