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Table 2 Comparison of the apparent absorptions of five SQV SDNs to that of standard SQV across differentiated Caco-2 monolayers after 1 hour of incubation (n=5)

From: Enhancement of saquinavir absorption and accumulation through the formation of solid drug nanoparticles

Sample Apparent absorption = PappAP-BL/ PappBL-AP
SQV SQV SDN 05 SQV SDN 06 SQV SDN 07 SQV SDN 09 SQV SDN 13
1 0.5 1.8 0.4 0.3 0.6 0.1
2 0.2 0.2 0.4 0.1 0.2 0.1
3 0.2 0.4 0.5 0.3 0.3 0.0
4 1.7 0.8 0.4 1.6 0.5 0.0
5 0.9 1.3 1.5 0.8 0.8 0.7
Mean 0.7 0.9 0.7 0.6 0.5 0.2
STDEV 0.6 0.7 0.5 0.6 0.2 0.3
   p = 0.61 p > 0.99 p = 0.88 p = 0.50 p = 0.06