Table 4 Intracellular accumulation of SQV, SQV combined with excipients for SQV 13 and the SQV SDNs in CEM and CEMVBL cells

Sample

1

2

3

4

5

Average

STDEV

p value

CEM SQV

1.5

1.3

1.8

1.6

1.4

1.5

0.2

CEM SQV+P

1.5

1.6

1.5

1.7

1.4

1.5

0.1

p = 0.97

CEM SQV 05

2.2

1.8

1.8

1.9

2.0

1.9

0.2

p = 0.03

CEM SQV 06

2.2

1.5

2.1

2.0

1.7

1.9

0.3

p = 0.04

CEM SQV 07

2.1

1.4

1.8

2.2

1.6

1.8

0.3

p = 0.12

CEM SQV 09

1.9

1.6

1.9

2.3

1.7

1.9

0.3

p = 0.04

CEM SQV 13

1.8

1.6

1.5

2.1

2.4

1.9

0.4

p = 0.10

Sample

1

2

3

4

5

Average

STDEV

p value

VBL SQV

1.0

1.1

1.3

1.4

1.5

1.3

0.2

VBL SQV+P

1.2

1.5

1.4

1.2

1.4

1.3

0.1

p = 0.48

VBL SQV 05

1.0

0.9

1.3

1.4

1.7

1.3

0.3

p = 0.99

VBL SQV 06

1.0

1.1

1.5

1.6

1.9

1.4

0.4

p = 0.49

VBL SQV 07

0.8

1.0

1.2

1.5

1.7

1.2

0.4

p = 0.93

VBL SQV 09

1.1

0.9

1.4

1.5

1.3

1.2

0.2

p = 0.92

VBL SQV 13

1.0

0.8

1.4

1.5

1.9

1.3

0.4

p = 0.80