Enhancement of saquinavir absorption and accumulation through the formation of solid drug nanoparticles

Table 4 Intracellular accumulation of SQV, SQV combined with excipients for SQV 13 and the SQV SDNs in CEM and CEMVBL cells

a) CEM cells
	Cellular accumulation ration (CAR)
Sample	1	2	3	4	5	Average	STDEV	p value
CEM SQV	1.5	1.3	1.8	1.6	1.4	1.5	0.2
CEM SQV+P	1.5	1.6	1.5	1.7	1.4	1.5	0.1	p = 0.97
CEM SQV 05	2.2	1.8	1.8	1.9	2.0	1.9	0.2	p = 0.03
CEM SQV 06	2.2	1.5	2.1	2.0	1.7	1.9	0.3	p = 0.04
CEM SQV 07	2.1	1.4	1.8	2.2	1.6	1.8	0.3	p = 0.12
CEM SQV 09	1.9	1.6	1.9	2.3	1.7	1.9	0.3	p = 0.04
CEM SQV 13	1.8	1.6	1.5	2.1	2.4	1.9	0.4	p = 0.10
b) CEM VBL cells
	Cellular accumulation ration (CAR)
Sample	1	2	3	4	5	Average	STDEV	p value
VBL SQV	1.0	1.1	1.3	1.4	1.5	1.3	0.2
VBL SQV+P	1.2	1.5	1.4	1.2	1.4	1.3	0.1	p = 0.48
VBL SQV 05	1.0	0.9	1.3	1.4	1.7	1.3	0.3	p = 0.99
VBL SQV 06	1.0	1.1	1.5	1.6	1.9	1.4	0.4	p = 0.49
VBL SQV 07	0.8	1.0	1.2	1.5	1.7	1.2	0.4	p = 0.93
VBL SQV 09	1.1	0.9	1.4	1.5	1.3	1.2	0.2	p = 0.92
VBL SQV 13	1.0	0.8	1.4	1.5	1.9	1.3	0.4	p = 0.80

ISSN: 2050-6511