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Table 4 Intracellular accumulation of SQV, SQV combined with excipients for SQV 13 and the SQV SDNs in CEM and CEMVBL cells

From: Enhancement of saquinavir absorption and accumulation through the formation of solid drug nanoparticles

a) CEM cells
  Cellular accumulation ration (CAR)   
Sample 1 2 3 4 5 Average STDEV p value
CEM SQV 1.5 1.3 1.8 1.6 1.4 1.5 0.2  
CEM SQV+P 1.5 1.6 1.5 1.7 1.4 1.5 0.1 p = 0.97
CEM SQV 05 2.2 1.8 1.8 1.9 2.0 1.9 0.2 p = 0.03
CEM SQV 06 2.2 1.5 2.1 2.0 1.7 1.9 0.3 p = 0.04
CEM SQV 07 2.1 1.4 1.8 2.2 1.6 1.8 0.3 p = 0.12
CEM SQV 09 1.9 1.6 1.9 2.3 1.7 1.9 0.3 p = 0.04
CEM SQV 13 1.8 1.6 1.5 2.1 2.4 1.9 0.4 p = 0.10
b) CEM VBL cells
  Cellular accumulation ration (CAR)
Sample 1 2 3 4 5 Average STDEV p value
VBL SQV 1.0 1.1 1.3 1.4 1.5 1.3 0.2  
VBL SQV+P 1.2 1.5 1.4 1.2 1.4 1.3 0.1 p = 0.48
VBL SQV 05 1.0 0.9 1.3 1.4 1.7 1.3 0.3 p = 0.99
VBL SQV 06 1.0 1.1 1.5 1.6 1.9 1.4 0.4 p = 0.49
VBL SQV 07 0.8 1.0 1.2 1.5 1.7 1.2 0.4 p = 0.93
VBL SQV 09 1.1 0.9 1.4 1.5 1.3 1.2 0.2 p = 0.92
VBL SQV 13 1.0 0.8 1.4 1.5 1.9 1.3 0.4 p = 0.80
  1. P = Excipients for SQV 13 sample
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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